Evidence map›Paper›PMID 26888713›Full record

SynthesisThe American journal of clinical nutrition2016

FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis.

Lingwei Xiang, Hongyu Wu, An Pan, Bhakti Patel, Guangda Xiang, Lu Qi, Robert C Kaplan, Frank Hu, Judith Wylie-Rosett, Qibin Qi

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 7 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 7 syntheses or guidelines pooled it, 106 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Lingwei XiangDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;
Hongyu WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
An PanSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;
Bhakti PatelDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;
Guangda XiangDepartment of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, China; and.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;
Frank HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Judith Wylie-RosettDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY;
Qibin QiDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY; qibin.qi@einstein.yu.edu.
Albert Einstein College of Medicine · USBrigham and Women's Hospital · USHarvard University · USHuazhong University of Science and Technology · CNWuhan General Hospital of Guangzhou · CN

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY E. PESSIN · 2015 to 2026
$27.7M
HIV Infection, Metabolites and Subclinical AtherosclerosisK01HL129892 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI QI, QIBIN · 2015 to 2018
$637k
NCI NIH HHS P30 CA013330NHLBI NIH HHS K01 HL129892NIDDK NIH HHS P30 DK020541
6 · The paper itself

Abstract

backgroundStudies have suggested that the fat mass and obesity-associated (FTO) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions, but results are inconsistent.

objectiveWe aimed to provide a summary of the literature evaluating the relation between the FTO genotype and weight loss in response to diet/lifestyle interventions.

designA search of English-language articles in the PubMed and Embase databases (through 30 April 2015) was performed. Eligible studies were diet/lifestyle weight-loss intervention studies conducted in adults that reported changes in body weight or body mass index (BMI) by the FTO variant rs9939609 (or its proxy). Differences in weight loss between FTO genotypes across studies were pooled with the use of fixed-effect models.

resultsA meta-analysis of 10 studies (comprising 6951 participants) that reported the results of additive genetic models showed that individuals with the FTO TA genotype and AA genotype (those with the obesity-predisposing A allele) had 0.18-kg (95% CI: -0.09-, 0.45-kg;P= 0.19; NS) and 0.44-kg (95% CI: 0.09-, 0.79-kg;P= 0.015) greater weight loss, respectively, than those with the TT genotype. A meta-analysis of 14 studies (comprising 7700 participants) that reported the results of dominant genetic models indicated a 0.20-kg (-0.43-, 0.04-kg) greater weight loss in the TA/AA genotype than in the TT genotype (P= 0.10). In addition, differences in weight loss between the AA genotype and TT genotype were significant in studies with a diet intervention only, adjustment for baseline BMI or body weight, and several other subgroups. However, the relatively small number of studies limited these stratified analyses, and there was no statistically significant difference between subgroups.

conclusionsThis meta-analysis suggests that individuals carrying the homozygous FTO obesity-predisposing allele may lose more weight through diet/lifestyle interventions than noncarriers. Our data provide evidence for genetic variability in response to diet/lifestyle interventions on weight loss, although clinical applications of these findings need further investigations.

Indexed as

Life StyleWeight LossAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody Mass IndexBody WeightDatabases, FactualDiet, ReducingGenetic Predisposition to DiseaseGenotypeHumansObesityPolymorphism, Single NucleotideProteinsRandomized Controlled Trials as TopicAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanProteinsdietFTO genotypelifestyle interventionmeta-analysisweight loss

Identifiers

PMID26888713
PMCPMC4807705
OpenAlexW2321294277

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.