Evidence map›Paper›PMID 26889771›Full record

ReviewNucleus (Austin, Tex.)2016

The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane.

Jens B Bosse, Lynn W Enquist

Abstract readReview
In one paragraph

Review in Nucleus (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jens B Bossea Heinrich Pette Institute, Leibniz Institute for Experimental Virology , Hamburg , Germany.
Lynn W Enquistb Department of Molecular Biology, Princeton University , Princeton , USA.

Funding

Genetic Analysis of Herpesvirus Tropism and VirulenceR37NS033506 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 2005 to 2020
$4.1M
GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCER01NS033506 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 1995 to 2016
$3.7M
Neuronal Spread of Herpesvirus InfectionR01NS060699 · NINDS · PRINCETON UNIVERSITY · PI ENQUIST, LYNN W. · 2008 to 2017
$3.6M
NINDS NIH HHS NS033506NINDS NIH HHS NS060699NINDS NIH HHS R01 NS033506NINDS NIH HHS R01 NS060699
6 · The paper itself

Abstract

Herpesviruses are large DNA viruses that utilize the host nucleus for genome replication as well as capsid assembly. After maturation, these 125 nm large capsid assemblies must cross the nucleoplasm to engage the nuclear envelope and bud into the cytoplasm. Here we summarize our recent findings how this motility is facilitated. We suggest that herpesvirus induced nuclear remodeling allows capsids to move by diffusion in the nucleus and not by motor-dependent transport.

Indexed as

AnimalsCapsidCytoplasmHerpesviridaeHumansNuclear Envelopecapsidegressherpesnuclear actinnucleusring-sheet

Identifiers

PMID26889771
PMCPMC4916875

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.