ArticleObesity (Silver Spring, Md.)2016
Brain imaging demonstrates a reduced neural impact of eating in obesity.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Exercise and diet effects on delay discounting and related neurobiology in adults with overweight or obesity: A randomized trial.Obesity (Silver Spring, Md.) · 2025Trial
- LEAP2 changes with body mass and food intake in humans and mice.The Journal of clinical investigation · 2019Trial
- Brain responses to food cue viewing in pregnant women with and without gestational diabetes mellitus.Communications medicine · 2026Article
- The Contribution of the Brain-Gut Axis to the Human Reward System.Biomedicines · 2024Review
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Functional Magnetic Resonance Imaging and Obesity-Novel Ways to Seen the Unseen.Journal of clinical medicine · 2022Review
- Cognition and brain oxygen metabolism improves after bariatric surgery-induced weight loss: A pilot study.Frontiers in endocrinology · 2022Article
- Double jeopardy: Comorbid obesity and cigarette smoking are linked to neurobiological alterations in inhibitory control during smoking cue exposure.Addiction biology · 2020Article
- Central Nervous System and Peripheral Hormone Responses to a Meal in Children.The Journal of clinical endocrinology and metabolism · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThis study investigated functional brain response differences to food in women with BMI either <25 kg/m(2) (lean) or >35 kg/m(2) (severe obesity). DESIGN AND
methodsThirty women, 18-65 years old, from academic medical centers participated. Baseline brain perfusion was measured with arterial spin labeling. Brain activity was measured via blood-oxygen-level-dependent functional magnetic resonance imaging in response to food cues, and appeal to cues was rated. Subjective hunger/fullness was reported pre- and post-imaging. After a standard meal, measures were repeated.
resultsWhen fasting, brain perfusion did not differ significantly between groups; and both groups showed significantly increased activity in the neo- and limbic cortices and midbrain compared with baseline (P < 0.05, family-wise-error whole-brain corrected). Once fed, the lean group showed significantly decreased activation in these areas, especially the limbic cortex, whereas the group with severe obesity showed no such decreases (P < 0.05, family-wise-error whole-brain corrected). After eating, appeal ratings of food decreased only in lean women. Within groups, hunger decreased (P < 0.001) and fullness increased (P < 0.001) fasted to fed.
conclusionsWhile fasting, brain response to food cues in women did not differ significantly despite BMI. After eating, brain activity quickly diminished in lean women but remained elevated in women with severe obesity. These brain activation findings confirm previous studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.