ArticleThe Journal of clinical endocrinology and metabolism2016
Metabolic Risk Factors and Type 2 Diabetes Incidence in American Indian Children.
Article in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Article
- A Cross-Sectional Study Investigating Associations between Personality Traits, Glycemic Control, and BMI in Persons with Diabetes: Lolland-Falster Health Study, Denmark.International journal of environmental research and public health · 2024Article
- Diabetes Complications among Inpatients with Childhood and Young Adult-Onset Type 1 and 2 Diabetes.Pediatric diabetes · 2024Article
- The Role of Childhood Obesity in Early-Onset Type 2 Diabetes Mellitus: A Scoping Review.Cureus · 2023Article
- Disparities in diabetes prevalence and management by race and ethnicity in the USA: defining a path forward.The lancet. Diabetes & endocrinology · 2023Review
- Article
- Increased Adiposity and Low Height-for-Age in Early Childhood Are Associated With Later Metabolic Risks in American Indian Children and Adolescents.The Journal of nutrition · 2022Article
- Association between Dietary Patterns Reflecting C-Reactive Protein and Metabolic Syndrome in the Chinese Population.Nutrients · 2022Article
- Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers.International journal of medical sciences · 2021Observational
- Use of sleeve gastrectomy in adolescents and young adults with severe obesity.Current opinion in pediatrics · 2020Review
- Obesogenic Behaviors and Depressive Symptoms' Influence on Cardiometabolic Risk Factors in American Indian Children.Journal of allied health · 2019Article
- Secular changes in physical growth and obesity among southwestern American Indian children over four decades.Pediatric obesity · 2018Article
- Plasma adrenomedullin level in children with obesity: relationship to left ventricular function.World journal of pediatrics : WJP · 2018Article
- Body Mass Index and Incident Type 1 and Type 2 Diabetes in Children and Young Adults: A Retrospective Cohort Study.Journal of the Endocrine Society · 2017Article
- Tribally Affiliated Child-Care Center Environment and Obesogenic Behaviors in Young Children.Journal of the Academy of Nutrition and Dietetics · 2017Article
- Exercise Intervention Improves the Metabolic Profile and Body Composition of Southwestern American Indian Adolescents.Journal of diabetes and obesity · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextData are lacking on how metabolic risk factors during childhood affect the long-term risk of type 2 diabetes.
objectivesAssess four metabolic risk factors as predictors of type 2 diabetes and determine whether the risk differs between younger and older children.
designIn a prospective cohort study conducted between 1965 and 2007, participants were followed for development of diabetes. Baseline measurements included body mass index (BMI), blood pressure, serum cholesterol, and 2-hour plasma glucose after an oral glucose tolerance test. Additional analyses divided subjects into two groups according to baseline age, 5–11 and 12–19 years.
settingGila River Indian Community in Arizona.
participantsA total of 5532 nondiabetic Pima Indian children 5–19 years old.
resultsA total of 1281 children developed diabetes (median follow-up, 12.4 years). Diabetes incidence was higher in overweight children (BMI ≥ 85th percentile) than in nonoverweight children. Nonoverweight children had the lowest risk of diabetes (20-year cumulative incidence, 9.5%), whereas overweight children with impaired glucose tolerance (2-hour glucose ≥ 140 mg/dL) had the highest (79.0%). The relative risk for children with metabolic abnormalities compared with their healthy counterparts was higher in younger children than in older children early in follow-up. BMI and 2-hour glucose were related to incident diabetes in multivariable models (predicted 15-year cumulative incidence for the highest vs lowest quartile was 3.9 and 1.8 times as high for BMI and 2-hour glucose, respectively; P < .001), whereas blood pressure and cholesterol were not.
conclusionsBMI and impaired glucose tolerance in children are strong predictors of type 2 diabetes. Other components of the “metabolic syndrome” are not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.