ArticleMenopause (New York, N.Y.)2016
Changes in heart rate variability during vasomotor symptoms among midlife women.
Article in Menopause (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women.Menopause (New York, N.Y.) · 2017Trial
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Menopausal Vasomotor Symptoms and Subclinical Atherosclerotic Cardiovascular Disease: A Population-Based Study.Journal of the American Heart Association · 2024Article
- An Evaluation of DNA Methylation Levels and Sleep in Relation to Hot Flashes: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Vasomotor symptoms and cardiovascular health: findings from the SWAN and the MsHeart/MsBrain studies.Climacteric : the journal of the International Menopause Society · 2024Review
- Influence of the menopausal transition on polysomnographic sleep characteristics: a longitudinal analysis.Sleep · 2021Article
- Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN.Journal of the American Heart Association · 2021 · on this mapArticle
- Article
- Hypertensive disorders of pregnancy and menopausal symptoms: a cross-sectional study from the data registry on experiences of aging, menopause, and sexuality.Menopause (New York, N.Y.) · 2020Article
- Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study.PloS one · 2020Observational
- Menopause and Brain Health: Hormonal Changes Are Only Part of the Story.Frontiers in neurology · 2020Review
- Article
- Childhood abuse and vasomotor symptoms among midlife women.Menopause (New York, N.Y.) · 2019Article
- Hot flashes and awakenings among midlife women.Sleep · 2019Article
- Hormone Replacement Therapy: Would it be Possible to Replicate a Functional Ovary?International journal of molecular sciences · 2018Review
- Vasomotor symptoms: natural history, physiology, and links with cardiovascular health.Climacteric : the journal of the International Menopause Society · 2018Review
- Symptoms of menopause - global prevalence, physiology and implications.Nature reviews. Endocrinology · 2018Review
- Article
- Association of Vasomotor Symptoms and Cardiac Autonomic Functions in Perimenopausal Women.Journal of mid-life healthArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveMost midlife women report vasomotor symptoms (VMS), yet their physiology remains poorly understood. This study tested whether acute decreases in cardiac vagal control would occur with VMS in a large sample of women monitored during wake and sleep.
methodsTwo hundred and fifteen nonsmoking women aged 40 to 60 years with evidence of VMS were included. Women were free of a history of clinical cardiovascular disease or arrhythmia; or use of insulin, beta blockers, calcium channel blockers, or medications impacting VMS. Women underwent 24 hours of ambulatory monitoring for physiological (sternal skin conductance) and self-report (electronic diary) measurement of VMS; heart rate variability (electrocardiogram); and respiratory rate. Changes in cardiac vagal control as assessed by respiratory sinus arrhythmia during VMS, relative to periods before and after VMS, were tested in linear mixed models.
resultsSignificant decreases in respiratory sinus arrhythmia were observed during physiologically measured VMS relative to periods preceding (b[SE] = 0.13 (0.004), P < 0.0001) and after the vasomotor symptoms (b[SE] = 0.13 (0.004), P < 0.0001), adjusted for age, race, body mass index, and sleep/wake status. Decreases were observed for women not aware of their VMS, and differences persisted controlling for respiration rate. Interactions indicated that respiratory sinus arrhythmia decreases were most pronounced during sleep and for younger women.
conclusionsPhysiologically measured VMS were accompanied by an inhibition of cardiac vagal control in a large sample of women. Changes were observed irrespective of whether the VMS were reported, were most pronounced during sleep, and were greatest among younger women. These findings contribute to the understanding of vasomotor symptom physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.