Evidence map›Paper›PMID 26928404›Full record

Trial reportJournal of endocrinological investigation2016

Association of autoimmune thyroid diseases, chronic atrophic gastritis and gastric carcinoid: experience from a single institution.

C Castoro, R Le Moli, M L Arpi, M Tavarelli, G Sapuppo, L Frittitta, S Squatrito, G Pellegriti

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Journal of endocrinological investigation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
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  11. Workup of Gastroenteropancreatic Neuroendocrine Tumors.Surgical oncology clinics of North America · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Autoimmune atrophic gastritis: current perspectives.Clinical and experimental gastroenterology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C CastoroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
R Le MoliDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
M L ArpiEndocrinology, Garibaldi-Nesima Hospital, Via Palermo n. 636, 95126, Catania, Italy.
M TavarelliDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
G SapuppoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
L FrittittaDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
S SquatritoDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
G PellegritiEndocrinology, Garibaldi-Nesima Hospital, Via Palermo n. 636, 95126, Catania, Italy. g.pellegriti@unict.it.
University of Catania · ITOspedale Garibaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAutoimmune polyendocrine syndromes (APS) type III are characterized by the association of autoimmune thyroid disease (ATD) with other autoimmune diseases such as diabetes, alopecia, pernicious anemia, vitiligo and chronic atrophic gastritis. A strong association between ATD and atrophic gastritis (AG) has been demonstrated. Moreover 10 % of patients affected by AG have a predisposition to develop gastric carcinoid and adenocarcinoma as a result of chronic hypergastrinemia caused by achlorhydria and subsequent ELC cells neoplastic transformation.

methodsThe aim of the study is to evaluate, in a consecutive series of patients followed for ATD in our outpatients clinic, the prevalence of AG. In the period 2004-2014, 242 patients with ATD underwent a screening performing APCA, Vitamin B12, ferritin, iron, and hemoglobin and red cells count measurements with subsequent gastroscopy in case of APCA positivity.

resultsWe found 57/242 (23.5 %) patients with APCA positivity. Of these patients 33/57 (57.8 %), 31 F and 2 M, were affected by Graves disease; 24/57 (42.1 %) 21 F and 3 M by Hashimoto thyroiditis; 10/57 (17.5 %) presented with anemia, 14/57 (24.5 %) with vitamin B12 deficiency, 9/57 (15.7 %) with iron deficiency. In 2/57 a gastric carcinoid was found.

conclusionsOur data confirm the high association rate of AG in ATD which frequently is not an isolated disease but configure the picture of APS type III and need to be followed accordingly. An early diagnosis may be useful for diagnosis of gastric carcinoids and to explain and treat a gastric related L-thyroxine malabsorption and presence of chronic unexplained anemia.

Indexed as

AdolescentAdultAgedAutoimmune DiseasesCarcinoid TumorChildChronic DiseaseFemaleGastritis, AtrophicGastroscopyHumansMaleMiddle AgedPrognosisRetrospective StudiesStomach NeoplasmsAutoimmune diseaseAutoimmune gastritisCarcinoidGraves’ diseaseThyroid disease

Identifiers

PMID26928404
OpenAlexW2288391133

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.