Evidence map›Paper›PMID 26960804›Full record

ArticleLipids in health and disease2016

Serum retinol binding protein 4 is negatively related to estrogen in Chinese women with obesity: a cross-sectional study.

Qian Li, Weiyun Wu, Huandong Lin, Xinxia Chang, Hua Bian, Mingfeng Xia, Hongmei Yan, Xin Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qian LiDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Weiyun WuDepartment of Clinical Laboratory, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Huandong LinDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xinxia ChangDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hua BianDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Mingfeng XiaDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Hongmei YanDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China. 13761666976@126.com.
Xin GaoDepartment of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai, 200032, China. zhongshan_endo@126.com.
Fudan University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between serum Retinol Binding Protein 4 (RBP4) and obesity is still controversial. Serum RBP4 levels varies by gender, and estradiol may play a role in the difference. To investigate the participation of sex hormones in the association of RBP4 and obesity in humans, we measured serum RBP4, BMI, and sex hormones in 87 women from the outpatient.

methodsEighty-seven subjects of Chinese women origin from the outpatient (aged 40.22 ± 15.54 years) were enrolled. Subjects with diseases affecting the metabolic state or not suitable to participate in this study were excluded. Anthropometrics and laboratory tests, including lipid profile, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), estradiol (E2),progesterone (PROG), testosterone (TESTO), and dehydroepiandrosterone (DHEA) were conducted. Serum RBP4 was detected by an enzyme immunoassay kit and validated by quantitative Western blotting.

resultsCirculating RBP4 levels were positively associated with BMI, waist circumference, waist-to-hip ratio (WHR), systolic and diastolic (SBP), diastolic blood pressure (DBP), triglycerides (TG), low high-density lipoprotein cholesterol(LDL-c), and testosterone (TESTO) in the total group. While only in obese individuals, serum RBP4 levels were negatively associated with E2. The highest value was in the subjects with both obesity and the low estrogen level. Multiple linear regression analysis revealed that RBP4 correlated independently with TG, TC and insulin in all subjects, TC in non- obese individuals. However, E2 were significantly associated with serum RBP4 only in obese individuals.

conclusionsRBP4 could be a marker of obesity-related factors; estrogen was negatively related to RBP4 and might be one of the influential factors.

Indexed as

AdultAsian PeopleBody Mass IndexCross-Sectional StudiesEstrogensFemaleHumansLinear ModelsMiddle AgedObesityRetinol-Binding Proteins, PlasmaTestosteroneTriglyceridesWaist CircumferenceEstrogensRBP4 protein, humanRetinol-Binding Proteins, PlasmaTestosteroneTriglycerides

Identifiers

PMID26960804
PMCPMC4784408
OpenAlexW2293258780

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.