Evidence map›Paper›PMID 26968879›Full record

SynthesisJournal of medical Internet research2016

Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis.

Cathrien R L Beishuizen, Blossom C M Stephan, Willem A van Gool, Carol Brayne, Ron J G Peters, Sandrine Andrieu, Miia Kivipelto, Hilkka Soininen, Wim B Busschers, Eric P Moll van Charante and 1 more

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical Internet research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 71 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05560737 unknown statusnot on this mapstarted 2021, after this paper: background citation

ODYSSEE-vCHAT Mental Health Study: A Virtual Community Promoting Health Literacy, Self-Care, and Peer Support for Heart Failure and Kidney Disease

Typeobservational_patient_registrySponsorUniversity Health Network, TorontoRan2021 to 2023Enrolled215ConditionsChronic Heart Failure, Chronic Kidney DiseasesArmsODYSSEE-vCHAT
NCT06274710 narecruitingnot on this mapstarted 2023, after this paper: background citation

Open Access Digital CommunitY Promoting Self-Care, Peer Support, and HEalth LitEracy (ODYSSEE) for Kidney Health (KH) Trial

TypeinterventionalSponsorUniversity Health Network, TorontoRan2023 to 2026Enrolled344ConditionsChronic Kidney DiseasesArmsODYSSEE-KH
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cathrien R L BeishuizenAcademic Medical Center, Department of Neurology, University of Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0003-0199-0723
Blossom C M StephanORCID http://orcid.org/0000-0002-1235-360X
Willem A van GoolORCID http://orcid.org/0000-0003-3174-8233
Carol BrayneORCID http://orcid.org/0000-0001-5307-663X
Ron J G PetersORCID http://orcid.org/0000-0002-3642-5022
Sandrine AndrieuORCID http://orcid.org/0000-0002-1142-770X
Miia KivipeltoORCID http://orcid.org/0000-0003-0992-3875
Hilkka SoininenORCID http://orcid.org/0000-0002-2785-9937
Wim B BusschersORCID http://orcid.org/0000-0002-3393-9511
Eric P Moll van CharanteORCID http://orcid.org/0000-0002-1489-5218
Edo RichardORCID http://orcid.org/0000-0002-7250-3390

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWeb-based interventions can improve single cardiovascular risk factors in adult populations. In view of global aging and the associated increasing burden of cardiovascular disease, older people form an important target population as well.

objectiveIn this systematic review and meta-analysis, we evaluated whether Web-based interventions for cardiovascular risk factor management reduce the risk of cardiovascular disease in older people.

methodsEmbase, Medline, Cochrane and CINAHL were systematically searched from January 1995 to November 2014. Search terms included cardiovascular risk factors and diseases (specified), Web-based interventions (and synonyms) and randomized controlled trial. Two authors independently performed study selection, data-extraction and risk of bias assessment. In a meta-analysis, outcomes regarding treatment effects on cardiovascular risk factors (blood pressure, glycated hemoglobin A1c (HbA1C), low-density lipoprotein (LDL) cholesterol, smoking status, weight and physical inactivity) and incident cardiovascular disease were pooled with random effects models.

resultsA total of 57 studies (N=19,862) fulfilled eligibility criteria and 47 studies contributed to the meta-analysis. A significant reduction in systolic blood pressure (mean difference -2.66 mmHg, 95% CI -3.81 to -1.52), diastolic blood pressure (mean difference -1.26 mmHg, 95% CI -1.92 to -0.60), HbA1c level (mean difference -0.13%, 95% CI -0.22 to -0.05), LDL cholesterol level (mean difference -2.18 mg/dL, 95% CI -3.96 to -0.41), weight (mean difference -1.34 kg, 95% CI -1.91 to -0.77), and an increase of physical activity (standardized mean difference 0.25, 95% CI 0.10-0.39) in the Web-based intervention group was found. The observed effects were more pronounced in studies with short (<12 months) follow-up and studies that combined the Internet application with human support (blended care). No difference in incident cardiovascular disease was found between groups (6 studies).

conclusionsWeb-based interventions have the potential to improve the cardiovascular risk profile of older people, but the effects are modest and decline with time. Currently, there is insufficient evidence for an effect on incident cardiovascular disease. A focus on long-term effects, clinical endpoints, and strategies to increase sustainability of treatment effects is recommended for future studies.

Indexed as

InternetRisk Reduction BehaviorAgedBlood PressureBody WeightCardiovascular DiseasesCholesterol, LDLGlycated HemoglobinHumansMiddle AgedMotor ActivityRandomized Controlled Trials as TopicRisk FactorsSedentary BehaviorSmokingSmoking CessationCholesterol, LDLGlycated Hemoglobinagingcardiovascular diseaseeHealthmeta-analysisolder peoplepreventionsystematic review

Identifiers

PMID26968879
PMCPMC4808240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.