ReviewTherapeutic advances in chronic disease2016
Opioid-induced constipation: advances and clinical guidance.
Review in Therapeutic advances in chronic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Acupuncture for postoperative gastrointestinal dysfunction in cancer: a systematic review and meta-analysis.Frontiers in oncology · 2023Pooled it
- Bilateral Rectus Sheath Block with Continuous Bupivacaine Infusions After Elective Open Gastrectomy: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2024Trial
- Trial
- The Influence of Renal or Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Naldemedine.Clinical pharmacology in drug development · 2020Trial
- Prevalence of opioid-induced constipation in the emergency department: a retrospective study.Internal and emergency medicine · 2026Article
- Early detection of opioid-induced constipation in patients initiating weak opioids for chronic non-cancer pain.Scientific reports · 2026Article
- Development and validation of a nomogram for predicting postoperative new-onset constipation in elderly patients undergoing hip fracture surgery.Scientific reports · 2025Article
- Transdermal fentanyl induced paralytic intestinal obstruction in advanced liver cancer: a case report.Frontiers in pharmacology · 2025Article
- Potential drug-induced constipation: A retrospective study using a Japanese claims database.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
- Guidelines for Rational Clinical Use of Fentanyl Transdermal Patch.Drug design, development and therapy · 2024Article
- Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis.Molecules (Basel, Switzerland) · 2023Review
- Regulation of enteric nervous system via sacral nerve stimulation in opioid-induced constipated rats.Frontiers in neuroscience · 2023Article
- Pain and Opioid-Induced Gut Microbial Dysbiosis.Biomedicines · 2022Review
- Sex-specific role for serotonin 5-HTNeuropharmacology · 2022Article
- Article
- Update on the role of naldemedine in opioid-induced constipation in patients with chronic noncancer pain.Therapeutic advances in gastroenterology · 2022Review
- Efficacy and Safety of Methylnaltrexone for the Treatment of Opioid-Induced Constipation: A Meta-analysis of Randomized Controlled Trials.Pain and therapy · 2021Review
- An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Spontaneous Recurrent Pneumoperitoneum due to Opioid-Induced Constipation: A Case Report.Cureus · 2020Article
- More opioids, more constipation? Evaluation of longitudinal total oral opioid consumption and self-reported constipation in patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently opioids are the most frequently used medications for chronic noncancer pain. Opioid-induced constipation is the most common adverse effect associated with prolonged use of opioids, having a major impact on quality of life. There is an increasing need to treat opioid-induced constipation. With the recent approval of medications for the treatment of opioid-induced constipation, there are several therapeutic approaches. This review addresses the clinical presentation and diagnosis of opioid-induced constipation, barriers to its diagnosis, effects of opioids in the gastrointestinal tract, differential tolerance to opiates in different gastrointestinal organs, medications approved and in development for the treatment of opioid-induced constipation, and a proposed clinical management algorithm for treating opioid-induced constipation in patients with noncancer pain.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.