Evidence map›Paper›PMID 26977429›Full record

ArticleData in brief2016

Summary of clinical and laboratory data of study subjects with and without DCE-MRI plaque measurements in the AIM-HIGH clinical trial.

Kevin D O'Brien, Daniel S Hippe, Huijun Chen, Moni B Neradilek, Jeffrey L Probstfield, Suzanne Peck, Daniel A Isquith, Gador Canton, Chun Yuan, Nayak L Polissar and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00880178. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00880178 completed

Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

Ran2008Enrolled324Registered outcomes5Posted comparisons0ConditionsAtherosclerosis, Cardiovascular Diseases, Coronary Disease, Heart DiseasesArmssimvastatin, Simvastatin and Extended-Release niacin
PMID 28279371PMID 25245415PMID 26708287PMID 25084698PMID 29301785other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kevin D O'BrienDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Daniel S HippeDepartment of Radiology, University of Washington, Seattle, WA, USA.
Huijun ChenCenter for Biomedical Imaging Research, Tsinghua University, Beijing, China.
Moni B NeradilekThe Mountain-Whisper-Light Statistics, Seattle, WA, USA.
Jeffrey L ProbstfieldDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Suzanne PeckCenter for Child Health, Behavior and Development, Seattle Children׳s Research Institute, Seattle, WA, USA.
Daniel A IsquithDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
Gador CantonDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.
Chun YuanDepartment of Radiology, University of Washington, Seattle, WA, USA.
Nayak L PolissarThe Mountain-Whisper-Light Statistics, Seattle, WA, USA.
Xue-Qiao ZhaoDivision of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
William S KerwinPresage Biosciences, Inc., Seattle, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This brief data article summarizes the clinical risk factors and laboratory data of a group of subjects recruited for the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides and Impact on Global Health Outcomes) and an associated magnetic resonance imaging (MRI) substudy. The sample is restricted to those on statin therapy at the time of enrollment and data are presented stratified by whether dynamic contrast enhanced MRI (DCE-MRI) markers of carotid plaque vascularity and inflammation were available or not. The data provided herein are directly related to the article "Longer Duration of Statin Therapy is Associated with Decreased Carotid Plaque Vascularity by Magnetic Resonance Imaging" [2].

Indexed as

AIM-HIGH, Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglyceride and Impact on Global Health OutcomesAtherosclerosisCarotid arteryDCE-MRI, dynamic contrast-enhanced magnetic resonance imagingInflammationKtrans, transfer constantMagnetic resonance imagingPlaqueStatinVp, fractional plasma volume

Identifiers

PMID26977429
PMCPMC4773570

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.