ArticleNature plants2016
Inositol transporters AtINT2 and AtINT4 regulate arsenic accumulation in Arabidopsis seeds.
Article in Nature plants, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 118 citations in OpenAlex.
- PromoterEco-Environment & Health · 2025Article
- KRN5b regulates maize kernel row number through mediating phosphoinositol signalling.Plant biotechnology journal · 2024Article
- Mitigating toxic metals contamination in foods: Bridging knowledge gaps for addressing food safety.Trends in food science & technology · 2024Article
- Review
- Structural assessment of OsNIP2;1 highlighted critical residues defining solute specificity and functionality of NIP class aquaporins.Journal of advanced research · 2024Article
- Endoplasmic reticulum stress-responsive microRNAs are involved in the regulation of abiotic stresses in wheat.Plant cell reports · 2023Article
- Microbial biochemical pathways of arsenic biotransformation and their application for bioremediation.Folia microbiologica · 2023Review
- Regulatory Mechanisms Underlying Arsenic Uptake, Transport, and Detoxification in Rice.International journal of molecular sciences · 2023Review
- Negative Impacts of Arsenic on Plants and Mitigation Strategies.Plants (Basel, Switzerland) · 2023Review
- Arsenic in medicine: past, present and future.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- VOZ1 and VOZ2 transcription factors regulate arsenic tolerance and distribution in rice and Arabidopsis.Frontiers in plant science · 2023Article
- WRKY transcription factors: a promising way to deal with arsenic stress in rice.Molecular biology reports · 2022Review
- Molecular insight into arsenic uptake, transport, phytotoxicity, and defense responses in plants: a critical review.Planta · 2022Review
- Metalloid transporters and their regulation in plants.Plant physiology · 2021Review
- The transcription factor MYB40 is a central regulator in arsenic resistance inPlant communications · 2021Article
- An amiRNA screen uncovers redundant CBF and ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses.Plant, cell & environment · 2021Article
- Phytoremediation Potential, Photosynthetic and Antioxidant Response to Arsenic-Induced Stress ofPlants (Basel, Switzerland) · 2020Article
- Genome-wide identification, expression, and association analysis of the monosaccharide transporter (MST) gene family in peanut (3 Biotech · 2020Article
- Arsenic Uptake and Accumulation Mechanisms in Rice Species.Plants (Basel, Switzerland) · 2020Review
- Selenium Biofortification and Interaction With Other Elements in Plants: A Review.Frontiers in plant science · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 7 institutions in 3 countries.
Funding
Abstract
Arsenic contamination of groundwater and soils threatens the health of tens of millions of people worldwide. Understanding the way in which arsenic is taken up by crops such as rice, which serve as a significant source of arsenic in the human diet, is therefore important. Membrane transport proteins that catalyse arsenic uptake by roots, and translocation through the xylem to shoots, have been characterized in a number of plants, including rice. The transporters responsible for loading arsenic from the xylem into the phloem and on into the seeds, however, are yet to be identified. Here, we show that transporters responsible for inositol uptake in the phloem in Arabidopsis also transport arsenic. Transformation of Saccharomyces cerevisiae with AtINT2 or AtINT4 led to increased arsenic accumulation and increased sensitivity to arsenite. Expression of AtINT2 in Xenopus laevis oocytes also induced arsenite import. Disruption of AtINT2 or AtINT4 in Arabidopsis thaliana led to a reduction in phloem, silique and seed arsenic concentrations in plants fed with arsenite through the roots, relative to wild-type plants. These plants also exhibited a large drop in silique and seed arsenic concentrations when fed with arsenite through the leaves. We conclude that in Arabidopsis, inositol transporters are responsible for arsenite loading into the phloem, the key source of arsenic in seeds.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.