Evidence map›Paper›PMID 27012149›Full record

SynthesisHeadache2016

Adipokines and Migraine: A Systematic Review.

B Lee Peterlin, Simona Sacco, Claudia Bernecker, Ann I Scher

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Headache, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04360148 (Randomized-controlled Study for Evaluation of Ketogenic Metabolic Nutritional Pattern in Subjects With High-frequency Episodic Migraine), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04360148 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized-controlled Study for Evaluation of Ketogenic Metabolic Nutritional Pattern in Subjects With High-frequency Episodic Migraine

TypeinterventionalSponsorNew Penta SRLRan2020 to 2021Enrolled58ConditionsMigraine, Ketogenic Dieting, Weight Loss, OverweightArmsvery-low-calorie-ketogenic-diet, hypocaloric-balanced-diet
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Headaches and obesity.Arquivos de neuro-psiquiatria · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

B Lee PeterlinJohns Hopkins University School of Medicine, Department of Neurology, Baltimore, MD, USA.
Simona SaccoUniversity of L'Aquila, Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, L'Aquila, Italy.
Claudia BerneckerMedical University of Graz, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Graz, Austria.
Ann I ScherUniformed Services University, Bethesda, MD, USA.
Johns Hopkins Medicine · USMedical University of Graz · ATUniformed Services University of the Health Sciences · USUniversity of L'Aquila · IT

Funding

Impact and Mechansims of Migraine Comorbidites on Migraine Onset and ProgressionK23NS078345 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETERLIN, BARBARA LEE · 2012 to 2016
$888k
NINDS NIH HHS K23 NS078345NINDS NIH HHS K23-NS078345
6 · The paper itself

Abstract

backgroundMigraine is comorbid with obesity. Recent research suggests an association between migraine and adipocytokines, proteins that are predominantly secreted from adipose tissue and which participate in energy homeostasis and inflammatory processes.

objectivesIn this review, we first briefly discuss the association between migraine and obesity and the importance of adipose tissue as a neuroendocrine organ. We then present a systematic review of the extant literature evaluating circulating levels of adiponectin and leptin in those with migraine.

methodsA search of the PubMed database was conducted using the keywords "migraine," "adiponectin," and "leptin." In addition reference lists of relevant articles were reviewed for possible inclusion. English language studies published between 2005 and 2015 evaluating circulating blood concentration of adiponectin or leptin in those with migraine were included.

conclusionsWhile the existing data are suggestive that adipokines may be associated with migraine, substantial study design differences and conflicting results limit definitive conclusions. Future research utilizing carefully considered designs and methodology is warranted. In particular careful and systematic characterization of pain states at the time of samples, as well as systematic consideration of demographic (e.g., age, sex) and other vital covariates (e.g., obesity status, lipids) are needed to determine if adipokines play a role in migraine pathophysiology and if any adipokine represents a viable, novel migraine biomarker, or drug target.

Indexed as

AdipokinesHumansMigraine DisordersObesityAdipokinesadipokinesadiponectinleptinmigraineobesity

Identifiers

PMID27012149
PMCPMC4836978
OpenAlexW2310079945

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.