Evidence map›Paper›PMID 27013319›Full record

ArticleCardiovascular diabetology2016

Oxidative stress, inflammation, endothelial dysfunction and incidence of type 2 diabetes.

Andrew O Odegaard, David R Jacobs, Otto A Sanchez, David C Goff, Alexander P Reiner, Myron D Gross

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 166 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 8 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04971252 completednot on this mapstarted 2021, after this paper: background citation

Impact of Type II Diabetes Mellitus on Basic Coagulation Profile and Platelet Indices in Non-dialysis Chronic Kidney Disease Patients

Typeobservational_patient_registrySponsorSohag UniversityRan2021 to 2023Enrolled150ConditionsRenal Disorder Associated With Type II Diabetes MellitusArmsHematologic tests for patients with diabetes mellitus and chronic kidney disease
NCT05072587 nacompletednot on this mapstarted 2021, after this paper: background citation

Dietary Oxysterols and β-Cell Function Among African Americans

TypeinterventionalSponsorMorehouse School of MedicineRan2021 to 2023Enrolled12ConditionsType 2 DiabetesArmsPlant-based diet with no oxysterols, Standard ADA Diet (SADA)
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 8 syntheses or guidelines pooled it, 290 citations in OpenAlex.

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  5. The influence of ICAM1 rs5498 on diabetes mellitus risk: evidence from a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019
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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Andrew O OdegaardDepartment of Epidemiology, School of Medicine, University of California-Irvine, Irvine, CA, 92697-7550, USA. aodegaar@uci.edu.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA.
Otto A SanchezDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA.
David C GoffDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Denver, USA.
Alexander P ReinerDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, USA.
Myron D GrossDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA.
University of Minnesota · USSeattle University · USUniversity of California, Irvine · USUniversity of Colorado Denver · US

Funding

EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSISR01HL053560 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GROSS, MYRON D, JACOBS, DAVID R · 1995 to 2014
$9.0M
Intramural NIH HHSNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS R01 HL053560NHLBI NIH HHS R01-HL-53560.NIA NIH HHS AG0005
6 · The paper itself

Abstract

backgroundOxidative stress, inflammation and endothelial dysfunction are interrelated factors in the etiology of cardiovascular disease, but their linkage to type 2 diabetes is less clear. We examined the association of these biomarkers with incident type 2 diabetes (T2D).

methodsAnalysis of 2339 participants in the community-based coronary artery risk development in young adults (CARDIA) study. Participants (age 40.1 ± 3.6 years, 44 % Black, 58 % women) were free of diabetes, and were followed 10 years. Cox regression was used to estimate hazard ratios (HRs) for incident T2D adjusting for the other biomarkers under study, demographic and lifestyle measures, dietary biomarkers, BMI (kg/m(2)) and metabolic syndrome components.

resultsF2-isoprostanes and oxidized LDL (oxidative stress) were positively associated with incident T2D, but the associations were attenuated by adjustment for BMI. C-reactive protein was positively associated with T2D even with full adjustment: HR (95 % CI) = 2.21 (1.26-3.88) for quartile 4 (Q4) v. quartile 1 (Q1). The HR (95 % CI) for T2D for biomarkers of endothelial dysfunction ICAM-1 and E-selectin for Q4 v. Q1 were 1.64 (0.96-2.81) and 1.68 (1.04-2.71) respectively, with full adjustment. Including these two markers in a common risk score incorporating BMI and clinical measures improved the prediction probability of T2D: relative risk for the average person classified up compared to the average person classified down: 1.09, (1.06-1.13), P < 0.0001.

conclusionsBiomarkers of inflammation and endothelial dysfunction were positively associated with incident T2D. ICAM-1 and E-selectin add to the prediction of T2D beyond a common risk score.

Indexed as

AdultBiomarkersBlack PeopleC-Reactive ProteinDiabetes Mellitus, Type 2EndotheliumFemaleFollow-Up StudiesHumansIncidenceInflammationMaleMiddle AgedOxidative StressRisk FactorsBiomarkersC-Reactive ProteinEndothelial dysfunctionIncidenceInflammationoxidative stressType 2 diabetesYoung adults

Identifiers

PMID27013319
PMCPMC4806507
OpenAlexW2303236807

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.