ReviewFrontiers in neuroscience2016
Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines.
Review in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Do manual therapies have a specific autonomic effect? An overview of systematic reviews.PloS one · 2021Pooled it
- Pooled it
- Autonomic correlates of osteopathic manipulative treatment on facial functional mapping: an innovative approach based on thermal imaging.Scientific reports · 2025Trial
- Applying an osteopathic intervention to improve mild to moderate mental health symptoms: a mixed-methods feasibility randomised trial.Chiropractic & manual therapies · 2024Trial
- Effect of osteopathic techniques on human resting muscle tone in healthy subjects using myotonometry: a factorial randomized trial.Scientific reports · 2022Trial
- Effect of manual approaches with osteopathic modality on brain correlates of interoception: an fMRI study.Scientific reports · 2020Trial
- Untangling the Osteopathic Gordian Knot: Reconceptualized Principles for Sustainable and Contemporary Clinical Practice-A Conceptual Perspective.Healthcare (Basel, Switzerland) · 2026Article
- Impact of touch interventions on brain activity in moderately preterm infants: study protocol for a pilot randomised controlled trial.BMJ open · 2025Article
- Article
- Article
- Patient-Practitioner-Environment Synchronization: Four-Step Process for Integrating Interprofessional and Distinctive Competencies in Osteopathic Practice-A Scoping Review with Integrative Hypothesis.Healthcare (Basel, Switzerland) · 2025Review
- Effect of osteopathic manipulative treatment on pain in palliative care patients: a randomized placebo-controlled clinical trial.Pain reports · 2025Article
- Posture-Dependent Modulation of Interoceptive Processing in Young Male Participants: A Heartbeat-Evoked Potential Study.The European journal of neuroscience · 2025Article
- The Effect of Osteopathic Visceral Manipulation on Quality of Life and Postural Stability in Women with Endometriosis and Women with Pelvic Organ Prolapse: A Non-Controlled Before-After Clinical Study.Journal of clinical medicine · 2025Article
- The effect of osteopathic manipulative treatment on lenght of stay and pain relief in pediatric appendectomy: a pilot non-randomized time-controlled clinical trial.Frontiers in pediatrics · 2025Article
- Epistemological Flexibility in Person-Centered Care: The Cynefin Framework for (Re)Integrating Indigenous Body Representations in Manual Therapy.Healthcare (Basel, Switzerland) · 2024Article
- Does Osteopathic Heart-Focused Palpation Modify Heart Rate Variability in Stressed Participants with Musculoskeletal Pain? A Randomised Controlled Pilot Study.Healthcare (Basel, Switzerland) · 2024Article
- Neurophysiology, Neuro-Immune Interactions, and Mechanobiology in Osteopathy in the Cranial Field: An Evidence-Informed Perspective for a Scientific Rationale.Healthcare (Basel, Switzerland) · 2023Article
- Review
- Effectiveness of Osteopathic Manipulative Treatment in Adults with Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Historically, approaches used in manual medicine to explain patient reported symptoms have been focused on the so-called exteroceptive paradigm. Arguably, this mindset lacks an appropriate "reading system" able to interpret musculoskeletal disorders from a different perspective, where the properties of the nervous system are embraced into a more holistic and functional-related context. Interestingly, if the underpinning mechanisms of a given treatment scenario/effect are taking into account, the majority of research outcomes focuses on a proprioceptive/exteroceptive explanation, leaving ting aside the additional or even central role of interoception. Currently, to date, the application of theoretical knowledge acquired on the relatively recent neuroscientific concepts and evidence concerning of interoception, sensitization, touch, autonomic functions, inflammation, and pain into a clinical/research manual medicine scenario is lacking, even if theoretically, the impact on the possible etiological mechanisms and treatment effects seems to be important. Here, we propose the conceptual foundations for a new way of interpreting and reading patients' clinical reported outcomes scenario based on interoception and sensitization. We argue that this will provide a foundation to create the ground for future research focusing on the hypotheses that manual therapies, specifically osteopathy, can intercede with sensitization states, at all levels, using interoceptive pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.