Evidence map›Paper›PMID 27060939›Full record

Trial reportJournal of Alzheimer's disease : JAD2016

Changes in Neural Connectivity and Memory Following a Yoga Intervention for Older Adults: A Pilot Study.

Harris A Eyre, Bianca Acevedo, Hongyu Yang, Prabha Siddarth, Kathleen Van Dyk, Linda Ercoli, Amber M Leaver, Natalie St Cyr, Katherine Narr, Bernhard T Baune and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of Alzheimer's disease : JAD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03447236 (An Evaluation of Changes in Brain Functional Connectivity Resulting From Cognitive Intervention by Means of the Feuerstein Instrumental Enrichment Program in Older People With Mild Cognitive Impairment), which is not on this map. Cited by 64 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03447236 nacompletednot on this mapstarted 2017, after this paper: background citation

An Evaluation of Changes in Brain Functional Connectivity Resulting From Cognitive Intervention by Means of the Feuerstein Instrumental Enrichment Program in Older People With Mild Cognitive Impairment (MCI)

TypeinterventionalSponsorRambam Health Care CampusRan2017 to 2019Enrolled28ConditionsMild Cognitive ImpairmentArmsFeuerstein Program
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  17. A Randomized Controlled Trial of Tai Chi Chih or Health Education for Geriatric Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
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  20. A randomized controlled trial of Kundalini yoga in mild cognitive impairment.International psychogeriatrics · 2017 · on this map
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Harris A EyreSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Bianca AcevedoSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Hongyu YangSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Prabha SiddarthSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Kathleen Van DykSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Linda ErcoliSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Amber M LeaverAhmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA.
Natalie St CyrSemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.
Katherine NarrAhmanson-Lovelace Brain Mapping Center, Department of Neurology, UCLA, Los Angeles, CA, USA.
Bernhard T BauneDiscipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia.
Dharma S KhalsaAlzheimer's Research and Prevention Foundation, Tucson, AZ, USA.
Helen LavretskySemel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA.

Funding

Brain aging and treatment response in geriatric depressionR01MH097892 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2013 to 2017
$3.5M
Methylphenidate Use to Improve Outcomes in Geriatric DepressionR01MH077650 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2008 to 2012
$1.8M
Neurobiological Mechanisms of Treatment Response in Geriatric DepressionK24MH086481 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2010 to 2014
$906k
NIMH NIH HHS K24 MH086481NIMH NIH HHS R01 MH077650NIMH NIH HHS R01 MH097892
6 · The paper itself

Abstract

backgroundNo study has explored the effect of yoga on cognitive decline and resting-state functional connectivity.

objectivesThis study explored the relationship between performance on memory tests and resting-state functional connectivity before and after a yoga intervention versus active control for subjects with mild cognitive impairment (MCI).

methodsParticipants ( ≥ 55 y) with MCI were randomized to receive a yoga intervention or active "gold-standard" control (i.e., memory enhancement training (MET)) for 12 weeks. Resting-state functional magnetic resonance imaging was used to map correlations between brain networks and memory performance changes over time. Default mode networks (DMN), language and superior parietal networks were chosen as networks of interest to analyze the association with changes in verbal and visuospatial memory performance.

resultsFourteen yoga and 11 MET participants completed the study. The yoga group demonstrated a statistically significant improvement in depression and visuospatial memory. We observed improved verbal memory performance correlated with increased connectivity between the DMN and frontal medial cortex, pregenual anterior cingulate cortex, right middle frontal cortex, posterior cingulate cortex, and left lateral occipital cortex. Improved verbal memory performance positively correlated with increased connectivity between the language processing network and the left inferior frontal gyrus. Improved visuospatial memory performance correlated inversely with connectivity between the superior parietal network and the medial parietal cortex.

conclusionYoga may be as effective as MET in improving functional connectivity in relation to verbal memory performance. These findings should be confirmed in larger prospective studies.

Indexed as

YogaBrainCognitive DysfunctionFunctional NeuroimagingHumansLearningMagnetic Resonance ImagingMemoryNeural PathwaysNeuropsychological TestsPilot ProjectsAgingcognitive declinememory trainingmild cognitive impairmentmind-bodyolder adultssubjective memory complaintsyoga

Identifiers

PMID27060939
PMCPMC4927889

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.