ArticleNature communications2016
The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Ion transport peptide regulates larval body water balance via a receptor guanylyl cyclase iniScience · 2026Article
- Pre- and postsynaptic upregulation of FasII synergistically underlies neuropathological and behavioral phenotypes in a Drosophila model of myotonic dystrophy.Nature communications · 2025Article
- Fas2EB112: a tale of two chromosomes.G3 (Bethesda, Md.) · 2024Article
- Article
- Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants.Journal of cell science · 2023Article
- Fasciclin 2 plays multiple roles in promoting cell migration within the developing nervous system of Manduca sexta.Developmental biology · 2023Article
- NHA1 is a cation/proton antiporter essential for the water-conserving functions of the rectal complex inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021Review
- Metabolically active and polyploid renal tissues rely on graded cytoprotection to drive developmental and homeostatic stress resilience.Development (Cambridge, England) · 2021Article
- A unique Malpighian tubule architecture inProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Basal microvilli define the metabolic capacity and lethal phenotype of pancreatic cancer.The Journal of pathology · 2021Article
- Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in theAmerican journal of physiology. Cell physiology · 2020Article
- Physiology, Development, and Disease Modeling in theGenetics · 2020Review
- Specialized stellate cells offer a privileged route for rapid water flux inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Regulation of actin-based apical structures on epithelial cells.Journal of cell science · 2018Review
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Multicellular organisms rely on cell adhesion molecules to coordinate cell-cell interactions, and to provide navigational cues during tissue formation. In Drosophila, Fasciclin 2 (Fas2) has been intensively studied due to its role in nervous system development and maintenance; yet, Fas2 is most abundantly expressed in the adult renal (Malpighian) tubule rather than in neuronal tissues. The role Fas2 serves in this epithelium is unknown. Here we show that Fas2 is essential to brush border maintenance in renal tubules of Drosophila. Fas2 is dynamically expressed during tubule morphogenesis, localizing to the brush border whenever the tissue is transport competent. Genetic manipulations of Fas2 expression levels impact on both microvilli length and organization, which in turn dramatically affect stimulated rates of fluid secretion by the tissue. Consequently, we demonstrate a radically different role for this well-known cell adhesion molecule, and propose that Fas2-mediated intermicrovillar homophilic adhesion complexes help stabilize the brush border.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.