Evidence map›Paper›PMID 27086854›Full record

ArticleBiochemical and biophysical research communications2016

Prenylation differentially inhibits insulin-dependent immediate early gene mRNA expression.

J Lee Franklin, Maggie O Amsler, Joseph L Messina

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Alterations of housekeeping proteins in human aged and diseased hearts.Pflugers Archiv : European journal of physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J Lee FranklinUniversity of Alabama at Birmingham, Department of Pathology, Division of Molecular and Cellular Pathology, Birmingham, AL 35294, USA.
Maggie O AmslerUniversity of Alabama at Birmingham, Department of Biology, Birmingham, AL 35294, USA.
Joseph L MessinaUniversity of Alabama at Birmingham, Department of Pathology, Division of Molecular and Cellular Pathology, Birmingham, AL 35294, USA; Veterans Administration Medical Center, Birmingham, AL 35294, USA. Electronic address: messinaj@uab.edu.
University of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5M
Hepatic Insulin Resistance Following HemorrhageR01DK062071 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MESSINA, JOSEPH LOUIS · 2004 to 2013
$2.9M
Trauma and Hemorrhage-Induced Skeletal Muscle Insulin ResistanceI01BX000611 · VA · BIRMINGHAM VA MEDICAL CENTER · PI MESSINA, JOSEPH LOUIS · 2009 to 2018
–
BLRD VA I01 BX000611NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK062071
6 · The paper itself

Abstract

Increased activity of prenyl transferases is observed in pathological states of insulin resistance, diabetes, and obesity. Thus, functional inhibitors of farnesyl transferase (FTase) and geranylgeranyl transferase (GGTase) may be promising therapeutic treatments. We previously identified insulin responsive genes from a rat H4IIE hepatoma cell cDNA library, including β-actin, EGR1, Pip92, c-fos, and Hsp60. In the present study, we investigated whether acute treatment with FTase and GGTase inhibitors would alter insulin responsive gene initiation and/or elongation rates. We observed differential regulation of insulin responsive gene expression, suggesting a differential sensitivity of these genes to one or both of the specific protein prenylation inhibitors.

Indexed as

ActinsAnimalsCell LineChaperonin 60Early Growth Response Protein 1Gene Expression RegulationHepatocytesInsulinMitochondrial ProteinsPrenylationProteinsProto-Oncogene Proteins c-fosRatsRNA, MessengerTranscription, GeneticActinsChaperonin 60Early Growth Response Protein 1Egr1 protein, ratHspd1 protein, ratInsulinMitochondrial Proteinspip92 protein, ratProteinsProto-Oncogene Proteins c-fosRNA, MessengerGene expressionImmediate early genesInsulinPrenylationTranscription

Identifiers

PMID27086854
PMCPMC5373655
OpenAlexW2340138515

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.