ReviewGenes2016
Epigenetic Biomarkers of Preterm Birth and Its Risk Factors.
Review in Genes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Perinatal stress and methylation of theEpigenetics · 2022Pooled it
- Chained Risk Assessment for Life-Long Disease Burden of Early Exposures - Demonstration of Concept Using Prenatal Maternal Smoking.International journal of environmental research and public health · 2020Pooled it
- Preterm Birth and Maternal Cardiovascular Risk.European cardiology · 2026Review
- Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing.Frontiers in epigenetics and epigenomics · 2025Article
- Epigenetic Biomarkers in Thrombophilia-Related Pregnancy Complications: Mechanisms, Diagnostic Potential, and Therapeutic Implications: A Narrative Review.International journal of molecular sciences · 2024Review
- Preterm birth buccal cell epigenetic biomarkers to facilitate preventative medicine.Scientific reports · 2022Article
- Burden and risk factors for antenatal depression and its effect on preterm birth in South Asia: A population-based cohort study.PloS one · 2022Article
- Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth.BMC genomics · 2021Article
- The relationship between air pollutants and maternal socioeconomic factors on preterm birth in California urban counties.Journal of exposure science & environmental epidemiology · 2021Article
- Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight.Clinical epigenetics · 2020Article
- Eating Disorders During Gestation: Implications for Mother's Health, Fetal Outcomes, and Epigenetic Changes.Frontiers in pediatrics · 2020Review
- Role ofJournal of genetics · 2020Article
- Effect of prematurity on genome wide methylation in the placenta.BMC medical genetics · 2019Article
- Article
- Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood.Scientific reports · 2018Article
- Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth.Obstetrics & gynecology science · 2018Article
- Extremely low gestational age and very low birthweight for gestational age are risk factors for autism spectrum disorder in a large cohort study of 10-year-old children born at 23-27 weeks' gestation.American journal of obstetrics and gynecology · 2017Article
- Worry about racial discrimination: A missing piece of the puzzle of Black-White disparities in preterm birth?PloS one · 2017Article
- The Role of miRNAs as Biomarkers for Pregnancy Outcomes: A Comprehensive Review.International journal of genomics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A biomarker is a biological measure predictive of a normal or pathogenic process or response. Biomarkers are often useful for making clinical decisions and determining treatment course. One area where such biomarkers would be particularly useful is in identifying women at risk for preterm delivery and related pregnancy complications. Neonates born preterm have significant morbidity and mortality, both in the perinatal period and throughout the life course, and identifying women at risk of delivering preterm may allow for targeted interventions to prevent or delay preterm birth (PTB). In addition to identifying those at increased risk for preterm birth, biomarkers may be able to distinguish neonates at particular risk for future complications due to modifiable environmental factors, such as maternal smoking or alcohol use during pregnancy. Currently, there are no such biomarkers available, though candidate gene and epigenome-wide association studies have identified DNA methylation differences associated with PTB, its risk factors and its long-term outcomes. Further biomarker development is crucial to reducing the health burden associated with adverse intrauterine conditions and preterm birth, and the results of recent DNA methylation studies may advance that goal.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.