Evidence map›Paper›PMID 27099249›Full record

Trial reportThe American journal of clinical nutrition2016

Plasma acylcarnitines and risk of cardiovascular disease: effect of Mediterranean diet interventions.

Marta Guasch-Ferré, Yan Zheng, Miguel Ruiz-Canela, Adela Hruby, Miguel A Martínez-González, Clary B Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó and 8 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.

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  18. Vegetarian Dietary Patterns and Diet-Related Metabolites Are Associated With Kidney Function in the Adventist Health Study-2 Cohort.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2026
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42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 2 countries.

Marta Guasch-FerréDepartments of Nutrition and Human Nutrition Department, Pere Virgili Research Institute, University Hospital of Sant Joan de Reus, Rovira i Virgili University, Reus, Spain; The Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain;ORCID http://orcid.org/0000-0002-5141-1796
Yan ZhengDepartments of Nutrition and.
Miguel Ruiz-CanelaThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra-Medical Research Institute of Navarra, Pamplona, Spain;
Adela HrubyDepartments of Nutrition and.
Miguel A Martínez-GonzálezThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Navarra-Medical Research Institute of Navarra, Pamplona, Spain;
Clary B ClishBroad Institute of MIT and Harvard University, Cambridge, MA;
Dolores CorellaThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Department of Preventive Medicine, University of Valencia, Valencia, Spain;
Ramon EstruchThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Department of Internal Medicine and.
Emilio RosThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Lipid Clinic, Department of Endocrinology and Nutrition, Biomedical Research Institute Agustí Pi Sunyer, Clinic Hospital, University of Barcelona, Barcelona, Spain;
Montserrat FitóThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Cardiovascular and Nutrition Research Group, Hospital del Mar Research Institute, Barcelona, Spain;
Courtney DennisBroad Institute of MIT and Harvard University, Cambridge, MA;
Isabel M Morales-GilDepartment of Infirmary, Faculty of Health Science, University of Malaga, Malaga, Spain;
Fernando ArósDepartment of Cardiology, University Hospital of Alava, Vitoria, Spain;
Miquel FiolInstitute of Health Sciences of University of Balearic Islands and Hospital Son Espases, Palma de Mallorca, Spain;
José LapetraThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Sevilla, Spain;
Lluís Serra-MajemThe Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas, Spain; and.
Frank B HuDepartments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jordi Salas-SalvadóHuman Nutrition Department, Pere Virgili Research Institute, University Hospital of Sant Joan de Reus, Rovira i Virgili University, Reus, Spain; The Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Institute Carlos III, Madrid, Spain; jordi.salas@urv.cat.ORCID http://orcid.org/0000-0003-2700-7459
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition · ESBroad Institute · USBrigham and Women's Hospital · USHealth Research Institute of the Balearic Islands · ESHospital Universitario Araba · ESUniversidad de Las Palmas de Gran Canaria · ESUniversidad de Málaga · ESUniversitat de València · ES

Funding

Mediterranean diet, Metabolites, and Cardiovascular DiseaseR01HL118264 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI HU, FRANK B, LAMUELA-RAVENTÓS, ROSA · 2013 to 2025
$6.8M
NHLBI NIH HHS R01 HL118264
6 · The paper itself

Abstract

backgroundPrevious studies have suggested that metabolite profiles of elevated acylcarnitines were associated with increased risk of cardiovascular disease (CVD) in populations with established coronary disease. However, to our knowledge, this association has not been evaluated in the context of primary cardiovascular prevention.

objectivesWe evaluated the association between 28 plasma acylcarnitine species and risk of incident CVD and the potential modifying effect of Mediterranean diet (MedDiet) interventions.

designWe measured plasma acylcarnitines with the use of high-throughput liquid chromatography-tandem mass spectrometry at baseline and after 1 y of follow-up, both individually and classified into short-, medium-, or long-chain scores, in a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED) study, which is a randomized Mediterranean dietary intervention for primary cardiovascular prevention. A randomly selected subcohort (n = 751) and all available incident CVD cases (n = 229) after 4.8 y of follow-up were included in the current study.

resultsAfter adjustment for age, sex, body mass index, and other CVD risk factors, participants in the highest quartile of baseline short- and medium-chain acylcarnitines had a higher risk of CVD than did participants in the lowest quartile [HRs: 1.80 (95% CI: 1.11, 2.91; P-trend 0.01) and 1.55 (95% CI: 1.01, 2.48; P-trend = 0.04), respectively]. Increased short-chain acylcarnitines after 1 y were associated with higher risks of total CVD and stroke. Participants with higher baseline concentrations of short-, medium-, and long-chain acylcarnitines who were randomly assigned to the control group had a higher risk of CVD than did subjects with lower concentrations of acylcarnitines who were assigned to the MedDiet group.

conclusionsOur data support the conclusion that metabolite profiles characterized by elevated concentrations of acylcarnitines are independently associated with risks of total CVD and stroke alone in participants at high risk of CVD. MedDiet interventions may mitigate the adverse associations shown between higher concentrations of acylcarnitines and CVD. This trial was registered at www.controlled-trials.com as ISRCTN35739639.

Indexed as

Diet, MediterraneanAgedBody Mass IndexCardiovascular DiseasesCarnitineCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsStrokeacylcarnitineCarnitineacylcarnitinescardiovascular diseaseMediterranean dietmetabolomicsPREDIMED

Identifiers

PMID27099249
PMCPMC4881000
OpenAlexW2337352325

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.