Combinations of Polymorphic Markers of Chemokine Genes, Their Receptors and Acute Phase Protein Genes As Potential Predictors of Coronary Heart Diseases.

T R Nasibullin, L F Yagafarova, I R Yagafarov, Y R Timasheva, V V Erdman, I A Tuktarova, O E Mustafina

Open access · hybridAbstract read

In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

0.8field-weighted citation impact, top 26% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

COVID-19: Mechanisms, risk factors, genetics, non-coding RNAs and neurologic impairments.Non-coding RNA research · 2023
Review
Genetic variants of MCP-1 and CCR2 genes and IgA nephropathy risk.Oncotarget · 2016
Article
Association of C-Reactive Protein (rs1205) Gene Polymorphism with Susceptibility to Psoriasis in South Indian Tamils.Journal of clinical and diagnostic research : JCDR · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

T R NasibullinInstitute of Biochemistry and Genetics, Ufa Research Center of the Russian Academy of Sciences, Ufa, the Republic of Bashkortostan, Prospect Octyabrya, 71, 450054, Russia.

L F YagafarovaMedical and sanitary unit of PJSC "Tatneft" and the city of Almetyevsk, Almetyevsk, the Republic of Tatarstan, Radischeva Str., 67, 423450, Russia.

I R YagafarovMedical and sanitary unit of PJSC "Tatneft" and the city of Almetyevsk, Almetyevsk, the Republic of Tatarstan, Radischeva Str., 67, 423450, Russia.

Y R TimashevaInstitute of Biochemistry and Genetics, Ufa Research Center of the Russian Academy of Sciences, Ufa, the Republic of Bashkortostan, Prospect Octyabrya, 71, 450054, Russia.

V V ErdmanInstitute of Biochemistry and Genetics, Ufa Research Center of the Russian Academy of Sciences, Ufa, the Republic of Bashkortostan, Prospect Octyabrya, 71, 450054, Russia.

I A TuktarovaInstitute of Biochemistry and Genetics, Ufa Research Center of the Russian Academy of Sciences, Ufa, the Republic of Bashkortostan, Prospect Octyabrya, 71, 450054, Russia.

O E MustafinaInstitute of Biochemistry and Genetics, Ufa Research Center of the Russian Academy of Sciences, Ufa, the Republic of Bashkortostan, Prospect Octyabrya, 71, 450054, Russia.

Russian Academy of Sciences · RUTatneft (Russia) · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis, the main factor in the development of coronary heart diseases (CHD), is an inflammatory response to endothelial layer damage in the arterial bed. We have analyzed the association between CHD and the polymorphic markers of genes that control the synthesis of proteins involved in the processes of adhesion and chemotaxis of immunocompetent cells: rs1024611 (-2518A>G, CCL2 gene), rs1799864 (V64I, CCR2 gene), rs3732378 (T280M, CX3CR1 gene), rs1136743 (A70V, SAA1 gene), and rs1205 (2042C>T, CRP gene) in 217 patients with CHD and 250 controls. Using the Monte Carlo method and Markov chains (APSampler), we revealed a combination of alleles/genotypes associated with both a reduced and increased risk of CHD. The most significant alleles/genotypes areSAA1*T/T+CRP*C+CX3CR1*G/A (P perm = 0.0056, OR = 0.07 95%CI 0.009-0.55), SAA1*T+CRP*T+CCR2*G/A+CX3CR1*G (P perm = 0.0063, OR = 14.58 95%CI 1.88-113.04), SAA1*T+CCR2*A+CCL2* G/G (P perm = 0.0351, OR = 10.77 95%CI 1.35-85.74).

Indexed as

APSamplercomplex traitscoronary heart diseasegenetic polymorphism

Identifiers

PMID27099791

PMCPMC4837578

OpenAlexW2951955438

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.