Evidence map›Paper›PMID 27100091›Full record

ArticlePloS one2016

Geographic Variation in Maternal Smoking during Pregnancy in the Missouri Adolescent Female Twin Study (MOAFTS).

Min Lian, Pamela A Madden, Michael T Lynskey, Graham A Colditz, Christina N Lessov-Schlaggar, Mario Schootman, Andrew C Heath

Open access · goldAbstract readTwin Study
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

  1. Child Salivary Cotinine Levels Related to Neighborhood Deprivation and Tobacco and Alcohol Retail Outlets.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
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  8. Tobacco Retail Outlets, Neighborhood Deprivation and the Risk of Prenatal Smoke Exposure.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2022
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  10. Neighborhood Deprivation is Associated with Increased Risk of Prenatal Smoke Exposure.Prevention science : the official journal of the Society for Prevention Research · 2022
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  11. Spatially Varying Associations of Neighborhood Disadvantage with Alcohol and Tobacco Retail Outlet Rates.International journal of environmental research and public health · 2022
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  12. Associations of Alcohol and Tobacco Retail Outlet Rates with Neighborhood Disadvantage.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Min LianDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, United States of America.
Pamela A MaddenCancer Prevention and Control Program, Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital, and Washington University School of Medicine, St. Louis, MO, United States of America.
Michael T LynskeyAddictions Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.
Graham A ColditzCancer Prevention and Control Program, Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital, and Washington University School of Medicine, St. Louis, MO, United States of America.
Christina N Lessov-SchlaggarCancer Prevention and Control Program, Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital, and Washington University School of Medicine, St. Louis, MO, United States of America.
Mario SchootmanCancer Prevention and Control Program, Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital, and Washington University School of Medicine, St. Louis, MO, United States of America.
Andrew C HeathCancer Prevention and Control Program, Alvin J. Siteman Cancer Center, Barnes-Jewish Hospital, and Washington University School of Medicine, St. Louis, MO, United States of America.
Jewish Hospital · USWashington University in St. Louis · USKing's College London · GB

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISMK05AA017688 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2008 to 2017
$1.9M
NEIGHBORHOOD, FAMILY AND INDIVIDUAL FACTORS IN ADOLESCENT DRINKINGR01AA021492 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C., SCHOOTMAN, MARIO · 2013 to 2016
$1.2M
GENE-NEIGHBORHOOD INTERACTION IN ADOLESCENT AND YOUNG ADULT SMOKINGK07CA178331 · NCI · WASHINGTON UNIVERSITY · PI LIAN, MIN · 2013 to 2017
$661k
NCI NIH HHS K07 CA178331NCI NIH HHS P30 CA091842NIAAA NIH HHS K05 AA017688NIAAA NIH HHS R01 AA021492
6 · The paper itself

Abstract

objectiveDespite well-known adverse health effects of maternal smoking during pregnancy (MSP), it is still unclear if MSP varies geographically and if neighborhood socioeconomic deprivation (SED) plays an important role in MSP. This study aims to investigate small-area geographic variation in MSP and examine the association of SED with MSP.

methodsThe Missouri Adolescent Female Twin Study (MOAFTS) is a cohort study of female like-sex twins born in Missouri to Missouri-resident parents during 1975-1985. Biological mothers completed a baseline interview in 1995-1998 and reported MSP with the twins. Residential address of the mother at birth was geocoded. We developed a census tract-level SED index using a common factor approach based on 21 area-level socioeconomic variables from the 1980 Census data. Multilevel logistic regressions estimated geographic heterogeneity (random effect) in MSP and the odds ratios (ORs, fixed effects) of neighborhood SED associated with MSP.

resultsOf 1658 MOAFTS mothers, 35.2% reported any MSP and 21.9% reported MSP beyond the first trimester. Neighborhood SED was associated with any MSP (the highest vs. the lowest quartile: OR = 1.90, 95% confidence interval [CI] = 1.40-2.57, Ptrend<0.001) and MSP beyond the first trimester (OR = 1.98, 95% CI = 1.38-2.85, Ptrend = 0.002) in unadjusted analyses. After adjusting for individual covariates (demographics, socioeconomic conditions, alcohol use, and parents' cohabitation), neighborhood SED was not associated with MSP, but geographic variation still persisted in MSP (variance = 0.41, P = 0.003) and in MSP beyond the first trimester (variance = 0.82, P<0.001).

conclusionsNeighborhood SED was associated with MSP in unadjusted analyses but this association could be explained by individual socioeconomic conditions. Nonetheless, significant geographic variation in MSP persisted and was not accounted for by differences in neighborhood SED. To develop effective interventions to reduce MSP, further studies are necessary to explore underlying reasons for its geographic variation.

Indexed as

AdolescentAdultFamily CharacteristicsFemaleGeographyHumansMissouriMothersOdds RatioPregnancyPregnancy ComplicationsProspective StudiesResidence CharacteristicsSmokingSocioeconomic FactorsYoung Adult

Identifiers

PMID27100091
PMCPMC4839577
OpenAlexW2342294734

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.