Evidence map›Paper›PMID 27106830›Full record

ReviewReviews in endocrine & metabolic disorders2016

Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism.

Steven K Malin, Zhenqi Liu, Eugene J Barrett, Arthur Weltman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Exercise and Reduced Nicotine Content Cigarettes in Adult Female Smokers: A Pilot Trial.International journal of environmental research and public health · 2022
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Journal of diabetes research · 2023
    Article
  12. Brain insulin resistance and cognitive function: influence of exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Review
  13. Prediabetes in Syria and Its Associated Factors: A Single-Center Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Prevalence of Pre-Diabetes and Its Associated Risk Factors in Rural Areas of Ningbo, China.International journal of environmental research and public health · 2016
    Article
  20. Introduction to Hanefeld Symposium: 40+ years of metabolic syndrome.Reviews in endocrine & metabolic disorders · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Steven K MalinApplied Metabolism & Physiology Laboratory, Department of Kinesiology, University of Virginia, 210 Emmet St., 225A Memorial Gymnasium, Charlottesville, VA, USA. skm6n@virginia.edu.
Zhenqi LiuDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, USA.
Eugene J BarrettDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, USA.
Arthur WeltmanApplied Metabolism & Physiology Laboratory, Department of Kinesiology, University of Virginia, 210 Emmet St., 225A Memorial Gymnasium, Charlottesville, VA, USA.
University of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prediabetes is a heterogeneous term that encompasses different origins of insulin resistance and insulin secretion that contribute to distinct patterns of hyperglycemia. In fact, prediabetes is an umbrella term that characterizes individuals at high risk for developing type 2 diabetes (T2D) and/or cardiovascular disease (CVD). Based on current definitions there are at least 3 distinct phenotypes of prediabetes: impaired fasting glucose (IFG), impaired glucose tolerant (IGT), or the combination of both (IFG + IGT). Each phenotype is clinically relevant as they are uniquely recognized as having different levels of risk for progressing to T2D and CVD. Herein, we discuss the underlying pathophysiology that characterizes IFG, IGT and the combination, as well as examine how some of these phenotypes appear resistant to traditional exercise interventions. We propose that substrate metabolism differences between the prediabetes phenotypes may be a unifying mechanism that explains the inter-subject variation in response to exercise seen across obese, metabolic syndrome, pre-diabetic and T2D patients in the current literature. Ultimately, a better understanding of the pathophysiologic mechanisms that govern disturbances responsible for fasting vs. postprandial hyperglycemia and the combination of both is important for designing optimal and personalized exercise treatment strategies that treat and prevent hyperglycemia and CVD risk.

Indexed as

Prediabetic StateExercise TherapyHumansInsulin ResistanceCardiovascular riskGlycemic controlMitochondrial functionβ-cell insulin secretion

Identifiers

PMID27106830
OpenAlexW2338215792

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.