Evidence map›Paper›PMID 27118566›Full record

ArticleInternational urology and nephrology2016

Associations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis.

Binnur Bagci, Gokhan Bagci, Can Huzmeli, Ilhan Sezgin, Ozturk Ozdemir

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International urology and nephrology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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  2. Association ofInternational journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Binnur BagciDepartment of Nutrition and Dietetics, School of Health Sciences, Cumhuriyet University, 58140, Sivas, Turkey. binnur.koksal@hotmail.com.
Gokhan BagciDepartment of Medical Genetics, School of Medicine, Cumhuriyet University, Sivas, Turkey.
Can HuzmeliDivision of Nephrology, Department of Internal Medicine, School of Medicine, Cumhuriyet University, Sivas, Turkey.
Ilhan SezginDepartment of Medical Genetics, School of Medicine, Cumhuriyet University, Sivas, Turkey.
Ozturk OzdemirDepartment of Medical Genetics, School of Medicine, Canakkale On Sekiz Mart University, Canakkale, Turkey.
Sivas Cumhuriyet Üniversitesi · TRÇanakkale Onsekiz Mart Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to investigate the associations of fractalkine receptor (CX3CR1) V249I, T280M and CCR5-59029 A/G gene polymorphisms in chronic renal failure (CRF) subjects undergoing hemodialysis and to evaluate possible associations of these polymorphisms with hypertension (HT), diabetes mellitus (DM) and atherosclerosis (AS).

methodsA total of 225 CRF subjects undergoing hemodialysis and 201 healthy controls were enrolled in the study. CRF subjects were divided into three major subgroups according to comorbidities including HT (n = 127), DM (n = 65) and AS (n = 33). Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism method.

resultsThe II genotype and I allele frequencies of CX3CR1 V249I polymorphism were found significantly more frequent in CRF subjects, CRF subjects with DM and CRF subjects with AS compared with controls (p < 0.05 for all comparisons). G allele frequency of CCR5 polymorphism was found significantly more prevalent in CRF subjects with DM than that of controls. Further, GG genotype and G allele frequencies of CCR5 polymorphism were significantly more prevalent in CRF subjects with AS compared with controls (p < 0.05). We also explored these polymorphisms among CRF subjects with and without following comorbidities: HT, DM, AS. We found significant association between CRF subjects with HT and without HT in terms of genotype and allele frequencies of V249I polymorphism (p < 0.05). CX3CR1 T280M polymorphism was not found significantly different in none of the comparisons.

conclusionThese data demonstrate possible associations between CX3CR1 V249I and CCR5-59029 A/G polymorphisms and/or HT, DM and AS in CRF subjects.

Indexed as

Genetic VariationAgedAtherosclerosisCase-Control StudiesChi-Square DistributionComorbidityCX3C Chemokine Receptor 1Diabetes MellitusFemaleGenetic Predisposition to DiseaseGenotypeHumansHypertensionKidney Failure, ChronicMaleMiddle AgedCCR5 protein, humanCX3C Chemokine Receptor 1CX3CR1 protein, humanReceptors, CCR5Receptors, ChemokineAtherosclerosisCCR5Chronic renal failureCX3CR1Diabetes mellitusHypertensionPolymorphism

Identifiers

PMID27118566
OpenAlexW2343590713

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.