Evidence map›Paper›PMID 27122001›Full record

ArticleScientific reports2016

Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo.

Firouzeh Dehghan, Fatemeh Hajiaghaalipour, Ashril Yusof, Sekaran Muniandy, Seyed Ali Hosseini, Sedigheh Heydari, Landa Zeenelabdin Ali Salim, Mohammad Ali Azarbayjani

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 90 citations in OpenAlex.

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  5. Effect ofNutrients · 2024
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  18. A review of the anti-diabetic potential of saffron.Nutrition and metabolic insights · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Firouzeh DehghanDepartment of Exercise Science, Sports Centre, University of Malaya, 50603 Kuala lumpur, Malaysia.
Fatemeh HajiaghaalipourDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Ashril YusofDepartment of Exercise Science, Sports Centre, University of Malaya, 50603 Kuala lumpur, Malaysia.
Sekaran MuniandyDepartment of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Seyed Ali HosseiniDepartment of Physical Education and Sport Science, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Sedigheh HeydariDepartment of Physical Education and Sport Science, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Landa Zeenelabdin Ali SalimDepartment of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Mohammad Ali AzarbayjaniDepartment of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
University of Malaya · MYIslamic Azad University, Marvdasht · IRIslamic Azad University Central Tehran Branch · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Saffron is consumed as food and medicine to treat several illnesses. This study elucidates the saffron effectiveness on diabetic parameters in-vitro and combined with resistance exercise in-vivo. The antioxidant properties of saffron was examined. Insulin secretion and glucose uptake were examined by cultured RIN-5F and L6 myotubes cells. The expressions of GLUT2, GLUT4, and AMPKα were determined by Western blot. Diabetic and non-diabetic male rats were divided into: control, training, extract treatment, training + extract treatment and metformin. The exercise and 40 mg/kg/day saffron treatments were carried out for six weeks. The antioxidant capacity of saffron was higher compare to positive control (P < 0.01). High dose of saffron stimulated insulin release in RIN-5F cells and improved glucose uptake in L6 myotubes. GLUT4 and AMPKα expressions increased in both doses of saffron (P < 0.01), whereas GLUT2 not changed (p > 0.05). Serum glucose, cholesterol, triglyceride, low-density lipoprotein, very low-density lipoprotein, insulin resistance, and glycated hemoglobin levels decreased in treated rats compared to untreated (p < 0.01). However, no significant differences were observed in the high-density lipoprotein, insulin, adiponectin, and leptin concentration levels in all groups (p > 0.05). The findings suggest that saffron consuming alongside exercise could improve diabetic parameters through redox-mediated mechanisms and GLUT4/AMPK pathway to entrap glucose uptake.

Indexed as

Physical Conditioning, AnimalAMP-Activated Protein KinasesAnimalsBiological TransportBlood GlucoseCell LineCrocusDiabetes Mellitus, ExperimentalGlucose Transporter Type 4Hypoglycemic AgentsInsulinInsulin-Secreting CellsInsulin SecretionMaleMetforminMyoblastsAMP-Activated Protein KinasesBlood GlucoseGlucose Transporter Type 4Hypoglycemic AgentsInsulinMetforminPlant Extracts

Identifiers

PMID27122001
PMCPMC4848502
OpenAlexW2343442988

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.