Evidence map›Paper›PMID 27165012›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Functional and anatomical evidence of cerebral tissue hypoxia in young sickle cell anemia mice.

Lindsay S Cahill, Lisa M Gazdzinski, Albert Ky Tsui, Yu-Qing Zhou, Sharon Portnoy, Elaine Liu, C David Mazer, Gregory Mt Hare, Andrea Kassner, John G Sled

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Trial
  2. Sickle cell mice exhibit elevated plasma bilirubin and altered intracranial cerebral blood velocities that are exacerbated by hypoxia-reoxygenation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  3. Article
  4. Review
  5. Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice.American journal of physiology. Heart and circulatory physiology · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Pathophysiology of Sickle Cell Disease.Annual review of pathology · 2019
    Review
  11. Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain.American journal of physiology. Regulatory, integrative and comparative physiology · 2018
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Lindsay S Cahill1 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Lisa M Gazdzinski1 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Albert Ky Tsui2 Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Yu-Qing Zhou1 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sharon Portnoy1 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Elaine Liu2 Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
C David Mazer2 Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Gregory Mt Hare2 Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, Department of Anesthesia, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Andrea Kassner4 Department of Medical Imaging, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
John G Sled1 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Hospital for Sick Children · CASt. Michael's Hospital · CAUniversity of Toronto · CASickKids Foundation · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral ischemia is a significant source of morbidity in children with sickle cell anemia; however, the mechanism of injury is poorly understood. Increased cerebral blood flow and low hemoglobin levels in children with sickle cell anemia are associated with increased stroke risk, suggesting that anemia-induced tissue hypoxia may be an important factor contributing to subsequent morbidity. To better understand the pathophysiology of brain injury, brain physiology and morphology were characterized in a transgenic mouse model, the Townes sickle cell model. Relative to age-matched controls, sickle cell anemia mice demonstrated: (1) decreased brain tissue pO

Indexed as

Anemia, Sickle CellAnimalsBrainBrain IschemiaCarotid ArteriesCerebrovascular CirculationGray MatterHypoxia, BrainMiceMice, TransgenicStrokeWhite Mattercerebral hypoxiacerebrovascular reactivitycontinuous arterial spin labelling MRISickle cell anemia mice

Identifiers

PMID27165012
PMCPMC5363475
OpenAlexW2358214529

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.