Evidence map›Paper›PMID 27172182›Full record

ArticleG3 (Bethesda, Md.)2016

Several Critical Cell Types, Tissues, and Pathways Are Implicated in Genome-Wide Association Studies for Systemic Lupus Erythematosus.

Lu Liu, Xianyong Yin, Leilei Wen, Chao Yang, Yujun Sheng, Yan Lin, Zhengwei Zhu, Changbing Shen, Yinjuan Shi, Yajie Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. IFN-BioMed research international · 2020
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. DNA-reactive B cells in lupus.Current opinion in immunology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lu LiuInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.
Xianyong YinInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Genetics, The Renaissance Computing Institute, University of North Carolina at Chapel Hill, North Carolina 27517.
Leilei WenInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.
Chao YangInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.
Yujun ShengInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Yan LinInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Zhengwei ZhuInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Changbing ShenInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Yinjuan ShiInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.
Yajie ZhengInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.
Sen YangInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Xuejun ZhangInstitute of Dermatology, Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Dermatology, Ministry of Education, State Key Lab of Dermatology Incubation Center, Anhui Medical University, Hefei, Anhui Province, 230032, China Key Laboratory of Gene Resource Utilization for Complex Diseases, Hefei, Anhui Province, 230032, China Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui Province, 230032, China.
Yong CuiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China wuhucuiyong@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to elucidate the cell types, tissues, and pathways influenced by common variants in systemic lupus erythematosus (SLE). We applied a nonparameter enrichment statistical approach, termed SNPsea, in 181 single nucleotide polymorphisms (SNPs) that have been identified to be associated with the risk of SLE through genome-wide association studies (GWAS) in Eastern Asian and Caucasian populations, to manipulate the critical cell types, tissues, and pathways. In the two most significant cells' findings (B lymphocytes and CD14+ monocytes), we subjected the GWAS association evidence in the Han Chinese population to an enrichment test of expression quantitative trait locus (QTL) sites and DNase I hypersensitivity, respectively. In both Eastern Asian and Caucasian populations, we observed that the expression level of SLE GWAS implicated genes was significantly elevated in xeroderma pigentosum B cells (P ≤ 1.00 × 10(-6)), CD14+ monocytes (P ≤ 2.74 × 10(-4)) and CD19+ B cells (P ≤ 2.00 × 10(-6)), and plasmacytoid dendritic cells (pDCs) (P ≤ 9.00 × 10(-6)). We revealed that the SLE GWAS-associated variants were more likely to reside in expression QTL in B lymphocytes (q1/q0 = 2.15, P = 1.23 × 10(-44)) and DNase I hypersensitivity sites (DHSs) in CD14+ monocytes (q1/q0 = 1.41, P = 0.08). We observed the common variants affected the risk of SLE mostly through by regulating multiple immune system processes and immune response signaling. This study sheds light on several immune cells and responses, as well as the regulatory effect of common variants in the pathogenesis of SLE.

Indexed as

Genome-Wide Association StudySignal TransductionCluster AnalysisGene Expression ProfilingGenetic Predisposition to DiseaseGenetic VariationGenomicsHumansImmune SystemLupus Erythematosus, SystemicOrgan SpecificityPolymorphism, Single NucleotideQuantitative Trait LociGenetics of Immunitygenome-wide association studiesSNPseasystemic lupus erythematosus

Identifiers

PMID27172182
PMCPMC4889647

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.