ArticlePlant signaling & behavior2016
Nicotine biosynthesis is regulated by two more layers: Small and long non-protein-coding RNAs.
Article in Plant signaling & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Non-coding RNA: a new perspective on the regulation of secondary metabolites in medicinal plants.Molecular horticulture · 2026Review
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Novel Differentially Expressed LncRNAs Regulate Artemisinin Biosynthesis inLife (Basel, Switzerland) · 2024Article
- A transcriptomic profile of topping responsive non-coding RNAs in tobacco roots (Nicotiana tabacum).BMC genomics · 2019Article
- Nicotine promotes the development of non-small cell lung cancer through activating LINC00460 and PI3K/Akt signaling.Bioscience reports · 2019Article
- Untargeted Metabolomics ofFrontiers in plant science · 2019Article
- Structure, target-specificity and expression of PN_LNC_N13, a long non-coding RNA differentially expressed in apomictic and sexual Paspalum notatum.Plant molecular biology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, many small RNAs and long non-protein-coding RNAs (lncRNAs) have been identified and characterized. They have been proved to play essential regulatory roles in gene expression in both primary and secondary metabolisms. In nature, many plants produce alkaloids. However, there are only few reports on the involvement of non-coding RNAs in alkaloid biosynthesis. Nicotine is major alkaloid in tobacco plants. Its biosynthesis and regulation in tobacco (Nicotiana tabacum) have been well studied; and major structural genes involved in the nicotine biosynthesis and transcriptional regulators related to its biosynthesis have been identified and characterized. In our recent studies, we identified a microRNA (nta-miRX27) and also a lncRNA (nta-eTMX27) as an endogenous target mimicry (eTM) in tobacco targeting the nicotine biosynthesis key gene QPT2 encoding quinolinate phosphoribosyltransferase (QPT) and thereby regulating the nicotine content. Their regulatory pattern leads us to conclude that nicotine biosynthesis is regulated by 2 more layers besides previously known mechanisms. Future study on the relationship between the non-coding RNAs and transcription factors in nicotine biosynthesis was discussed in this article.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.