Observational studyRheumatology (Oxford, England)2016
The relationship between three-dimensional knee MRI bone shape and total knee replacement-a case control study: data from the Osteoarthritis Initiative.
Observational study in Rheumatology (Oxford, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Study TPX-100-5: intra-articular TPX-100 significantly delays pathological bone shape change and stabilizes cartilage in moderate to severe bilateral knee OA.Arthritis research & therapy · 2021Trial
- CT-based 3D bone shape modes are associated with clinically meaningful functional improvement after total knee arthroplasty.Osteoarthritis and cartilage open · 2026Article
- Bone Shape Feature Differences in Single and Recurrent Patellar Dislocations via Statistical Shape Modeling.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Three-dimensional magnetic resonance imaging-based registration techniques and statistical shape analysis for knee osteoarthritis.Scientific reports · 2025Article
- Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes.Osteoarthritis and cartilage open · 2025Article
- Bone shape changes over two years following acute anterior cruciate ligament injury: Reconstructed vs non-reconstructed knees.Osteoarthritis and cartilage open · 2025Article
- Pain Assessment in Osteoarthritis: Present Practices and Future Prospects Including the Use of Biomarkers and Wearable Technologies, and AI-Driven Personalized Medicine.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Review
- The changes in 3D bone morphology mediate the association between meniscal extrusion and radiographic progression of osteoarthritis: data from the Osteoarthritis Initiative.Quantitative imaging in medicine and surgery · 2025Article
- Foundations of a knee joint digital twin from qMRI biomarkers for osteoarthritis and knee replacement.NPJ digital medicine · 2025Article
- Association Between Tibiofemoral Bone Shape Features and Retears After Anterior Cruciate Ligament Reconstruction.Orthopaedic journal of sports medicine · 2024Article
- Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank.Osteoarthritis and cartilage open · 2024Article
- Prognostic value of B-score for predicting joint replacement in the context of osteoarthritis phenotypes: Data from the osteoarthritis initiative.Osteoarthritis and cartilage open · 2024Article
- 3-dimensional bone shape and knee osteoarthritis: What have we learned?Osteoarthritis imaging · 2024Article
- Comparison of 3D quantitative osteoarthritis imaging biomarkers from paired CT and MR images: data from the IMI-APPROACH study.BMC musculoskeletal disorders · 2023Article
- Radiographic Biomarkers for Knee Osteoarthritis: A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Investigating acute changes in osteoarthritic cartilage by integrating biomechanics and statistical shape models of bone: data from the osteoarthritis initiative.Magma (New York, N.Y.) · 2022Article
- Fully Automatic Knee Joint Segmentation and Quantitative Analysis for Osteoarthritis from Magnetic Resonance (MR) Images Using a Deep Learning Model.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- A Machine Learning Model to Predict Knee Osteoarthritis Cartilage Volume Changes over Time Using Baseline Bone Curvature.Biomedicines · 2022Article
- Subchondral tibial bone texture of conventional X-rays predicts total knee arthroplasty.Scientific reports · 2022Article
- Novel nomogram for predicting the progression of osteoarthritis based on 3D-MRI bone shape: data from the FNIH OA biomarkers consortium.BMC musculoskeletal disorders · 2021Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveThere is growing understanding of the importance of bone in OA. Our aim was to determine the relationship between 3D MRI bone shape and total knee replacement (TKR).
methodsA nested case-control study within the Osteoarthritis Initiative cohort identified case knees with confirmed TKR for OA and controls that were matched using propensity scores. Active appearance modelling quantification of the bone shape of all knee bones identified vectors between knees having or not having OA. Vectors were scaled such that -1 and +1 represented the mean non-OA and mean OA shapes.
resultsCompared to controls (n = 310), TKR cases (n = 310) had a more positive mean baseline 3D bone shape vector, indicating more advanced structural OA, for the femur [mean 0.98 vs -0.11; difference (95% CI) 1.10 (0.88, 1.31)], tibia [mean 0.86 vs -0.07; difference (95% CI) 0.94 (0.72, 1.16)] and patella [mean 0.95 vs 0.03; difference (95% CI) 0.92 (0.65, 1.20)]. Odds ratios (95% CI) for TKR per normalized unit of 3D bone shape vector for the femur, tibia and patella were: 1.85 (1.59, 2.16), 1.64 (1.42, 1.89) and 1.36 (1.22, 1.50), respectively, all P < 0.001. After including Kellgren-Lawrence grade in a multivariable analysis, only the femur 3D shape vector remained significantly associated with TKR [odds ratio 1.24 (1.02, 1.51)].
conclusion3D bone shape was associated with the endpoint of this study, TKR, with femoral shape being most associated. This study contributes to the validation of quantitative MRI bone biomarkers for OA structure-modification trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.