Observational studyJournal of diabetes research2016
Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes.
Observational study in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Relationship between hemoglobin levels and diabetic retinopathy in Chinese type 2 diabetes mellitus populations: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Risk Factors for Diabetic Retinopathy Change With Diabetes Duration: Synergistic Effect of Long Duration and Anemia.Journal of diabetes research · 2026Article
- Lower hemoglobin levels may increase the risk of diabetic retinopathy in patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Association between Hemoglobin-albumin-lymphocyte-platelet score and all-cause or cardiovascular mortality in patients with diabetes or prediabetes: mediated effects of renal function.BMC cardiovascular disorders · 2025Article
- Association of hemoglobin with decreased prevalence of diabetic retinopathy among Tibetan male patients.Scientific reports · 2025Article
- Hemoglobin mediates the link between the 'weekend warrior' physical activity pattern and diabetic retinopathy.Scientific reports · 2025Article
- Retrospective database study on risk factors for diabetic retinopathy and diabetic kidney disease in Japanese patients with diabetes mellitus.Journal of diabetes investigation · 2025Article
- The Relationship Between Hemoglobin Levels and Proliferative Diabetic Retinopathy in Type 2 Diabetes Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Renal dysfunction associated with clinical response to intravitreal conbercept therapy for diabetic macular edema.International journal of ophthalmology · 2025Article
- Correlating the Optical Coherence Tomography Patterns and Biomarkers of Diabetic Macular Edema with Hemoglobin Level in Diabetic Kidney Disease.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Article
- Development and validation of a simple and practical model for early detection of diabetic macular edema in patients with type 2 diabetes mellitus using easily accessible systemic variables.Journal of translational medicine · 2024Observational
- In blood we trust: anemia as a negative healing prognostic factor in diabetic foot patients.Acta diabetologica · 2024Article
- The L-shape relationship between hemoglobin, albumin, lymphocyte, platelet score and the risk of diabetic retinopathy in the US population.Frontiers in endocrinology · 2024Article
- The relationship between diabetic retinopathy and diabetic nephropathy in type 2 diabetes.Frontiers in endocrinology · 2024Article
- Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge.Journal of clinical medicine · 2023Review
- Characterization of peripheral blood inflammatory indicators and OCT imaging biological markers in diabetic retinopathy with or without nephropathy.Frontiers in endocrinology · 2023Article
- Correlation of hemoglobin levels with diabetic retinopathy in US adults aged ≥40 years: the NHANES 2005-2008.Frontiers in endocrinology · 2023Article
- Can the level of HbABMC ophthalmology · 2022Article
- Bias or biology? Importance of model interpretation in machine learning studies from electronic health records.JAMIA open · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM). Methods. Cross-sectional, case-control study (N = 312) with T2DM: 153 individuals with DR and 159 individuals with no DR. Participants were classified according to the severity of DR and the presence of retinal ischemia or macular oedema. Hematological variables were collected by standardized methods. Three logistic models were adjusted to ascertain the association between hematologic variables with the severity of DR and the presence of retinal ischemia or macular oedema. Results. Individuals with severe DR showed significantly lower hemoglobin, hematocrit, and erythrocyte levels compared with those with mild disease and in individuals with retinal ischemia and macular oedema compared with those without these disorders. Hemoglobin was the only factor that showed a significant inverse association with the severity of DR [beta-coefficient = -0.52, P value = 0.003] and retinal ischemia [beta-coefficient = -0.49, P value = 0.001]. Lower erythrocyte level showed a marginally significant association with macular oedema [beta-coefficient = -0.86, P value = 0.055]. Conclusions. In patients with DR, low blood oxygen-transport capacity was associated with more severe DR and the presence of retinal ischemia. Low hemoglobin levels may have a key role in the development and progression of DR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.