SynthesisScientific reports2016
Anemia increases the mortality risk in patients with stroke: A meta-analysis of cohort studies.
Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pooled it
- CASR rs1801725 polymorphism is associated with the risk and prognosis of colorectal cancer: A case-control study.Journal of clinical laboratory analysis · 2020Pooled it
- Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis.European journal of epidemiology · 2020Pooled it
- Abnormal bowel movement frequency increases the risk of rectal cancer: evidence from cohort studies with one million people.Bioscience reports · 2020Pooled it
- Associations of Anemia With Outcomes in Patients With Spontaneous Intracerebral Hemorrhage: A Meta-Analysis.Frontiers in neurology · 2019Pooled it
- Trial
- Association of anemia with cardiovascular and cancer mortality among stroke survivors: A cohort study (NHANES 1999-2018).Medicine · 2025Article
- Development and validation of a dynamic nomogram for predicting in-hospital mortality in acute massive cerebral infarction: a retrospective study in a Chinese population.European journal of medical research · 2025Article
- Impact of Body Mass Index on Clinical Outcomes After Thrombectomy for Acute Ischemic Stroke in a Japanese Population.Stroke (Hoboken, N.J.) · 2025Article
- Assessing anemia in stroke patients through virtual non-contrast imaging with photon-counting detector CT: validation on supra-aortic vessel CT-Angiography.Neuroradiology · 2025Article
- Hemoglobin-to-Red Cell Distribution Width Ratio Was Associated with Cardiovascular Diseases and Death.Journal of clinical medicine · 2025Article
- Anemia and outcome of patients with ischemic stroke in a referral hospital in Cameroon.eNeurologicalSci · 2025Article
- Acute Ischemic Stroke Secondary to Severe Anemia From Upper Gastrointestinal Bleeding: A Case Report.Cureus · 2025Article
- Assessment of anemia recovery using peripheral blood smears by deep semi-supervised learning.Annals of hematology · 2025Article
- The association of hemoglobin levels and balance function in patients with stroke: a multicenter study in China.Frontiers in neuroscience · 2025Article
- Recurrent Ischemic Stroke and Transient Ischemic Attack: Risk of Single and Multiple Recurrence.Journal of clinical medicine · 2024Article
- Association between baseline hemoglobin level and early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Readmission Trends and Outcomes of Transcatheter Edge-to-Edge Repair of Mitral Regurgitation With and Without Anemia.Cureus · 2024Article
- Stroke risk in rheumatoid arthritis patients: exploring connections and implications for patient care.Clinical and experimental medicine · 2024Review
- Association of hemoglobin-to-red cell distribution width ratio with the three-month outcomes in patients with acute ischemic stroke.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The impact of anemia on the outcome of patients with stroke remains inconsistent. We performed a meta-analysis of cohort studies to assess the mortality risk in stroke patients with and without anemia. Systematic searches were conducted in the PubMed, China National Knowledge Infrastructure, Web of Science and Wanfang databases to identify relevant studies from inception to November 2015. The estimated odds ratio with a 95% confidence interval was pooled. subgroup analyses and sensitivity analyses were also conducted. We used Begg's funnel plot and Egger's test to detect the potential publication bias. Thirteen cohort studies with a total of 19239 patients with stroke were included in this meta-analysis. The heterogeneity among studies was slight (I(2) = 59.0%, P = 0.031). The results from a random-effect model suggest that anemia is associated with an increased mortality risk in patients with stroke (adjusted odds ratio = 1.39, 95% confidence interval: 1.22-1.58, P < 0.001). The subgroup analyses are consistent with the total results. This meta-analysis of 13 cohort studies finds that anemia increases the mortality risk in patients with stroke. Future studies should perform longer follow-up to confirm this finding and explore its possible mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.