ArticleeLife2016
Multisensory integration in the developing tectum is constrained by the balance of excitation and inhibition.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Neuro-cortical signatures of attention in uni- and multi-sensory audio-visual processing in children.Neuroscience · 2026Article
- Assessing circuit function in the developingFrontiers in behavioral neuroscience · 2026Review
- Article
- Characterization of NaLife science alliance · 2024Article
- Effects of developmental alcohol exposure on cortical multisensory integration.The European journal of neuroscience · 2023Article
- Morphology and Dendrite-Specific Synaptic Properties of Midbrain Neurons Shape Multimodal Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Using superior colliculus principles of multisensory integration to reverse hemianopia.Neuropsychologia · 2020Article
- Spatial receptive field shift by preceding cross-modal stimulation in the cat superior colliculus.The Journal of physiology · 2018Article
- Direct intertectal inputs are an integral component of the bilateral sensorimotor circuit for behavior in Xenopus tadpoles.Journal of neurophysiology · 2018Article
- Multisensory Integration Uses a Real-Time Unisensory-Multisensory Transform.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Multisensory temporal function and EEG complexity in patients with epilepsy and psychogenic nonepileptic events.Epilepsy & behavior : E&B · 2017Article
- Article
- Pulsed Stimuli Elicit More Robust Multisensory Enhancement than Expected.Frontiers in integrative neuroscience · 2017Article
- Emergence of Selectivity to Looming Stimuli in a Spiking Network Model of the Optic Tectum.Frontiers in neural circuits · 2016Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Multisensory integration (MSI) is the process that allows the brain to bind together spatiotemporally congruent inputs from different sensory modalities to produce single salient representations. While the phenomenology of MSI in vertebrate brains is well described, relatively little is known about cellular and synaptic mechanisms underlying this phenomenon. Here we use an isolated brain preparation to describe cellular mechanisms underlying development of MSI between visual and mechanosensory inputs in the optic tectum of Xenopus tadpoles. We find MSI is highly dependent on the temporal interval between crossmodal stimulus pairs. Over a key developmental period, the temporal window for MSI significantly narrows and is selectively tuned to specific interstimulus intervals. These changes in MSI correlate with developmental increases in evoked synaptic inhibition, and inhibitory blockade reverses observed developmental changes in MSI. We propose a model in which development of recurrent inhibition mediates development of temporal aspects of MSI in the tectum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.