Evidence map›Paper›PMID 27251684›Full record

Observational studyBMJ open2016

Evolution of target organ damage and haemodynamic parameters over 4 years in patients with increased insulin resistance: the LOD-DIABETES prospective observational study.

Manuel Ángel Gómez-Marcos, José Ignacio Recio-Rodríguez, María Carmen Patino-Alonso, Cristina Agudo-Conde, Emiliano Rodríguez-Sanchez, Jose Angel Maderuelo-Fernandez, Leticia Gómez-Sánchez, Marta Gomez-Sanchez, Luís García-Ortiz, LOD-DIABETES Group

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01065155 (Central Blood Pressure and Pulse Wave Velocity), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01065155 completednot on this map

Central Blood Pressure and Pulse Wave Velocity: Relationship to Target Organ Damage and Cardiovascular Morbidity-mortality in Diabetic Patients. An Observational Prospective Study. LOD-DIABETES: Study Protocol

TypeobservationalSponsorFundacion para la Investigacion y Formacion en Ciencias de la SaludRan2010 to 2016Enrolled110ConditionsDiabetes, Cardiovascular Disease
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Manuel Ángel Gómez-MarcosPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Medicine Department, University of Salamanca, Salamanca, Spain Statistics Department, University of Salamanca, Salamanca, Spain.
José Ignacio Recio-RodríguezPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Medicine Department, University of Salamanca, Salamanca, Spain.
María Carmen Patino-AlonsoPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Biomedical and Diagnostic Sciences Department, University of Salamanca, Salamanca, Spain.
Cristina Agudo-CondePrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Medicine Department, University of Salamanca, Salamanca, Spain.
Emiliano Rodríguez-SanchezPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Medicine Department, University of Salamanca, Salamanca, Spain Statistics Department, University of Salamanca, Salamanca, Spain.
Jose Angel Maderuelo-FernandezPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Medicine Department, University of Salamanca, Salamanca, Spain.
Leticia Gómez-SánchezPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
Marta Gomez-SanchezPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
Luís García-OrtizPrimary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain Castilla and León Health Service-SACYL, REDIAPP: Research Network on Preventive Activities and Health Promotion, Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain Medicine Department, University of Salamanca, Salamanca, Spain LOD-DIABETES Group, REDIAPP: Research Network on Preventive Activities and Health Promotion, Salamanca, Spain.
LOD-DIABETES Group
Instituto de Investigación Biomédica de Salamanca · ESUniversidad de Salamanca · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe prospectively examined the impact of type 2 diabetes compared with metabolic syndrome (MetS) on the development of vascular disease over 4 years as determined by anatomic and functional markers of vascular disease. By comparing the vascular outcomes of the 2 disorders, we seek to determine the independent effect of elevated glucose levels on vascular disease.

setting2 primary care centres in Salamanca, Spain.

participantsWe performed a prospective observational study involving 112 patients (68 with type 2 diabetes and 44 with MetS) who were followed for 4 years. PRIMARY AND SECONDARY OUTCOME MEASURES: Measurements included blood pressure, blood glucose, lipids, smoking, body mass index, waist circumference, Homeostasis Model Assessment Insulin Resistance (HOMA-IR), hs-c-reactive protein and fibrinogen levels. We also evaluated vascular, carotid intima media thickness (IMT), pulse wave velocity (PWV) and ankle/brachial index, heart and renal target organ damage (TOD). The haemodynamic parameters were central (CAIx) and peripheral (PAIx) augmentation indices.

resultsIn year 4, participants with type 2 diabetes had increased IMT thickness. These patients had more plaques and an IMT>0.90 mm. In participants with MetS, we only found an increase in the number of plaques. We found no changes in PWV, CAIx and PAIx. The patients with diabetes had a greater frequency of vascular TOD. There were no differences neither in renal nor cardiac percentage of TOD in the patients with MetS or diabetes mellitus type 2.

conclusionsThis prospective study showed that the evolution of vascular TOD is different in participants with type 2 diabetes compared with those with MetS. While IMT and PWV increased in type 2 diabetes, these were not modified in MetS. The renal and cardiac TOD evolution, as well as the PAIx and CAIx, did not change in either group. TRIAL REGISTRATION NUMBER: NCT01065155; Results.

Indexed as

Insulin ResistanceAgedAnkle Brachial IndexBlood PressureBlood Pressure DeterminationCarotid Intima-Media ThicknessC-Reactive ProteinDiabetes Mellitus, Type 2FemaleHumansKidneyMaleMetabolic SyndromeMiddle AgedProspective StudiesPulse Wave AnalysisC-Reactive ProteinArterial stiffnessDrug treatmentMetabolic syndromeTarget organ damageType 2 diabetes mellitus

Identifiers

PMID27251684
PMCPMC4893862
OpenAlexW2411073714

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.