Evidence map›Paper›PMID 27257919›Full record

SynthesisPloS one2016

Association between Asthma and Autism Spectrum Disorder: A Meta-Analysis.

Zhen Zheng, Li Zhang, Tingting Zhu, Jichong Huang, Yi Qu, Dezhi Mu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  13. Association between atopic diseases and neurodevelopmental disabilities in a longitudinal birth cohort.Autism research : official journal of the International Society for Autism Research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zhen ZhengDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Li ZhangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Tingting ZhuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Jichong HuangDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Yi QuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Dezhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China.
Sichuan University · CNWest China Second University Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe conducted a meta-analysis to summarize the evidence from epidemiological studies of the association between asthma and autism spectrum disorder (ASD).

methodsA literature search was conducted using PubMed, Embase, and Cochrane library for studies published before February 2nd, 2016. Observational studies investigating the association between asthma and ASD were included. A random effects model was used to calculate the pooled risk estimates for the outcome. Subgroup analysis was used to explore potential sources of heterogeneity and publication bias was estimated using Begg's and Egger's tests.

resultsTen studies encompassing 175,406 participants and 8,809 cases of ASD were included in this meta-analysis. In the cross-sectional studies, the prevalence of asthma in ASD was 20.4%, while the prevalence of asthma in controls was 15.4% (P < 0.001). The pooled odds ratio (OR) for the prevalence of asthma in ASD in the cross-sectional studies was 1.26 (95% confidence interval (CI): 0.98-1.61) (P = 0.07), with moderate heterogeneity (I2 = 65.0%, P = 0.02) across studies. In the case-control studies, the pooled OR for the prevalence of asthma in ASD was 0.98 (95% CI: 0.68-1.43) (P = 0.94), and there was no evidence of an association between asthma and ASD. No evidence of significant publication bias on the association between asthma and ASD was found.

conclusionsIn conclusion, the results of this meta-analysis do not suggest an association between asthma and ASD. Further prospective studies ascertaining the association between asthma and ASD are warranted.

Indexed as

AdolescentAdultAlgorithmsAsthmaAutism Spectrum DisorderChildChild, PreschoolFemaleHumansMaleModels, StatisticalObservational Studies as TopicOdds RatioPrevalenceResearch DesignRisk Factors

Identifiers

PMID27257919
PMCPMC4892578
OpenAlexW2422348410

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.