Evidence map›Paper›PMID 27293447›Full record

ReviewStem cells international2016

Stem Cell Therapy for Treatment of Ocular Disorders.

Padma Priya Sivan, Sakinah Syed, Pooi-Ling Mok, Akon Higuchi, Kadarkarai Murugan, Abdullah A Alarfaj, Murugan A Munusamy, Rukman Awang Hamat, Akihiro Umezawa, Suresh Kumar

Open access · goldAbstract readReview
In one paragraph

Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders.International journal of molecular sciences · 2019
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 6 countries.

Padma Priya SivanDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia; Department of Basic Medical Science and Department of Surgical Sciences, Ajman University of Science and Technology-Fujairah Campus, Al Fujairah, UAE.
Sakinah SyedDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.
Pooi-Ling MokDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia; Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.
Akon HiguchiDepartment of Chemical and Materials Engineering, National Central University, Jhong-li, Taoyuan 32001, Taiwan; Department of Botany and Microbiology, King Saud University, Riyadh 11451, Saudi Arabia; Department of Reproduction, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Kadarkarai MuruganDivision of Entomology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu, India; Department of Zoology, Thiruvalluvar University, Serkkadu, Vellore 632 115, India.
Abdullah A AlarfajDepartment of Botany and Microbiology, King Saud University, Riyadh 11451, Saudi Arabia.
Murugan A MunusamyDepartment of Botany and Microbiology, King Saud University, Riyadh 11451, Saudi Arabia.
Rukman Awang HamatDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.
Akihiro UmezawaDepartment of Reproduction, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
Suresh KumarDepartment of Medical Microbiology and Parasitology, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor, Malaysia.
Universiti Putra Malaysia · MYKing Saud University · SANational Center For Child Health and Development · JPBharathiar University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sustenance of visual function is the ultimate focus of ophthalmologists. Failure of complete recovery of visual function and complications that follow conventional treatments have shifted search to a new form of therapy using stem cells. Stem cell progenitors play a major role in replenishing degenerated cells despite being present in low quantity and quiescence in our body. Unlike other tissues and cells, regeneration of new optic cells responsible for visual function is rarely observed. Understanding the transcription factors and genes responsible for optic cells development will assist scientists in formulating a strategy to activate and direct stem cells renewal and differentiation. We review the processes of human eye development and address the strategies that have been exploited in an effort to regain visual function in the preclinical and clinical state. The update of clinical findings of patients receiving stem cell treatment is also presented.

Identifiers

PMID27293447
PMCPMC4884591
OpenAlexW2354545778

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.