Evidence map›Paper›PMID 27314008›Full record

ArticleBioMed research international2016

The CYBA Gene (⁎)49A>G Polymorphism (rs7195830) Is Associated with Hypertension in Patients with Coronary Artery Disease.

Tomasz Nowak, Paweł Niemiec, Sylwia Górczyńska-Kosiorz, Anna Balcerzyk, Tomasz Iwanicki, Jolanta Krauze, Wladyslaw Grzeszczak, Anna Ochalska-Tyka, Joanna Iwanicka, Iwona Zak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Tomasz NowakSchool of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Paweł NiemiecSchool of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Sylwia Górczyńska-KosiorzSchool of Medicine and Division of Dentistry in Zabrze, Department of Internal Medicine, Diabetes and Nephrology, Medical University of Silesia, 3 Maja Street 13-18, 41-800 Zabrze, Poland.
Anna BalcerzykSchool of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Tomasz IwanickiSchool of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Jolanta Krauze1st Department of Cardiac Surgery/2nd Department of Cardiology, American Heart of Poland, S. A. Armii Krajowej Street 101, 43-316 Bielsko-Biala, Poland.
Wladyslaw GrzeszczakSchool of Medicine and Division of Dentistry in Zabrze, Department of Internal Medicine, Diabetes and Nephrology, Medical University of Silesia, 3 Maja Street 13-18, 41-800 Zabrze, Poland.
Anna Ochalska-TykaRegional Centre of Blood Donation and Blood Treatment in Raciborz, Sienkiewicza Street 3, 47-400 Raciborz, Poland.
Joanna IwanickaSchool of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Iwona ZakSchool of Health Sciences in Katowice, Department of Biochemistry and Medical Genetics, Medical University of Silesia, Medyków Street 18, 40-752 Katowice, Poland.
Medical University of Silesia · PLAmerican Heart of Poland · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose. Single nucleotide polymorphisms of the CYBA gene may modify the risk of coronary artery disease (CAD). The aim of the present study was to investigate whether the (⁎)49A>G (rs7195830) polymorphism is associated with CAD. Materials and Methods. CYBA gene (⁎)49A>G polymorphism was determined in 481 subjects: 242 patients with premature CAD and 239 age and sex matched controls using the fluorescently labeled allele-specific oligonucleotides method. Results. The frequency of the (⁎)49G allele carrier state was significantly higher in patients than in controls (84.8% versus 76.6%, resp., P = 0.020), as well as the frequency of the (⁎)49G allele (62.2% versus 54.0%, P = 0.009). Both factors were associated with CAD in the analyzed population (OR = 1.70, 95% CI: 1.04-2.76 for GG+AG versus AA and OR = 1.40, 95% CI: 1.08-1.83 for (⁎)49G versus  (⁎)49A). Carrier state of the (⁎)49G allele was a stronger and independent risk factor for CAD among women (OR = 4.35, 95% CI: 1.50-13.20, P = 0.002), as well as the (⁎)49G allele (OR = 2.25, 95% CI: 1.34-3.77, P = 0.001). The (⁎)49G allele carrier state was also associated with left ventricular hypertrophy in patients with coronary artery disease (P = 0.015). Conclusion. The CYBA gene (⁎)49A>G polymorphism modifies the risk of coronary artery disease.

Indexed as

Polymorphism, Single NucleotideAdultAllelesCase-Control StudiesCoronary Artery DiseaseCoronary VesselsFemaleGenotypeHeterozygoteHumansHypertensionHypertrophy, Left VentricularLipidsMaleMiddle AgedNADPH OxidasesCYBA protein, humanLipidsNADPH OxidasesOligonucleotides

Identifiers

PMID27314008
PMCPMC4895038
OpenAlexW2400879969

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.