Evidence map›Paper›PMID 27314543›Full record

ReviewThe American journal of drug and alcohol abuse2016

Exercise as an adjunctive treatment for cannabis use disorder.

Angelique G Brellenthin, Kelli F Koltyn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of drug and alcohol abuse, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Reinforcing exercise to improve drug abuse treatment outcomes: A randomized controlled study in a substance use disorder outpatient treatment setting.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
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  12. 24-h Movement Guidelines and Substance Use among Adolescents: A School-Based Cross-Sectional Study.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Angelique G Brellenthina Department of Kinesiology , University of Wisconsin-Madison , Madison , WI , USA.
Kelli F Koltyna Department of Kinesiology , University of Wisconsin-Madison , Madison , WI , USA.

Funding

Comparative effects of exercise and treatment-as-usual on abstinence, craving, and the endocannabinoid system in cannabis usersR36DA040140 · NIDA · UNIVERSITY OF WISCONSIN-MADISON · PI BRELLENTHIN, ANGELIQUE GABRIELLE · 2015 to 2015
$54k
NIDA NIH HHS R36 DA040140
6 · The paper itself

Abstract

backgroundDespite cannabis being the most widely used illicit substance in the United States, individuals diagnosed with cannabis use disorder (CUD) have few well-researched, affordable treatment options available to them. Although found to be effective for improving treatment outcomes in other drug populations, exercise is an affordable and highly accessible treatment approach that has not been routinely investigated in cannabis users.

objectivesThe aim of this paper is to inform the topic regarding exercise's potential as an adjunctive treatment for individuals with CUD.

methodsWe reviewed the evidence surrounding cannabis use and its current treatment in the United States, explored the rationale for including exercise in the treatment of substance use disorders (SUDs), and in particular, proposed a biological mechanism (i.e., endocannabinoids (eCBs)) that should be examined when utilizing exercise for the treatment of CUD.

resultsCannabis use is widespread and increasing in the United States. Chronic, heavy cannabis use may dysregulate the endogenous cannabinoid system, which has implications for several psychobiological processes that interact with the eCB system such as reward processing and the stress response. Given that exercise is a potent activator of the eCB system, it is mechanistically plausible that exercise could be an optimal method to supplement cessation efforts by reducing psychophysical withdrawal, managing stress, and attenuating drug cravings.

conclusionWe suggest there is a strong behavioral and physiological rationale to design studies which specifically assess the efficacy of exercise, in combination with other therapies, in treating CUD. Moreover, it will be especially important to include the investigation of psychobiological mechanisms (e.g., eCBs, hippocampal volume), which have been associated with both exercise and SUDs, to examine the broader impact of exercise on behavioral and physiological responses to treatment.

Indexed as

Exercise TherapyCombined Modality TherapyEndocannabinoidsHumansMarijuana AbuseEndocannabinoidsanandamidecannabis use disorderendocannabinoidExercisetreatment

Identifiers

PMID27314543
PMCPMC5055462

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.