Evidence map›Paper›PMID 27322970›Full record

ReviewRadiology2016

Imaging of Brown Adipose Tissue: State of the Art.

Srihari C Sampath, Srinath C Sampath, Miriam A Bredella, Aaron M Cypess, Martin Torriani

Registry-linked trialAbstract readReview
In one paragraph

Review in Radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06440122 (The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06440122 unknown statusnot on this mapstarted 2024, after this paper: background citation

The Incidence and Outcomes of Metabolically Active Brown Adipose Tissue (aBAT) in Patients With Pheochromocytoma or Paraganglioma (PPGLs)

TypeobservationalSponsorKing's College Hospital NHS TrustRan2024 to 2024Enrolled100ConditionsPheochromocytoma, ParagangliomaArmsFDG-PET Scan
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. White adipose tissue uptake onRadiology case reports · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Srihari C SampathFrom Musculoskeletal Biology and Bioimaging, Department of Pharmacology, Genomics Institute of the Novartis Research Foundation, San Diego, Calif (Srihari Sampath, Srinath Sampath); Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114 (M.B., M.T.); and Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md (A.M.C.).
Srinath C SampathFrom Musculoskeletal Biology and Bioimaging, Department of Pharmacology, Genomics Institute of the Novartis Research Foundation, San Diego, Calif (Srihari Sampath, Srinath Sampath); Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114 (M.B., M.T.); and Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md (A.M.C.).
Miriam A BredellaFrom Musculoskeletal Biology and Bioimaging, Department of Pharmacology, Genomics Institute of the Novartis Research Foundation, San Diego, Calif (Srihari Sampath, Srinath Sampath); Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114 (M.B., M.T.); and Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md (A.M.C.).
Aaron M CypessFrom Musculoskeletal Biology and Bioimaging, Department of Pharmacology, Genomics Institute of the Novartis Research Foundation, San Diego, Calif (Srihari Sampath, Srinath Sampath); Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114 (M.B., M.T.); and Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md (A.M.C.).
Martin TorrianiFrom Musculoskeletal Biology and Bioimaging, Department of Pharmacology, Genomics Institute of the Novartis Research Foundation, San Diego, Calif (Srihari Sampath, Srinath Sampath); Division of Musculoskeletal Imaging and Intervention, Massachusetts General Hospital and Harvard Medical School, 55 Fruit St, Yawkey 6E, Boston, MA 02114 (M.B., M.T.); and Translational Physiology Section, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md (A.M.C.).

Funding

Physiological Responses to Activation of Human Brown Adipose TissueZIADK075116 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI CYPESS, AARON · 2015 to 2025
$6.1M
6 · The paper itself

Abstract

The rates of diabetes, obesity, and metabolic disease have reached epidemic proportions worldwide. In recent years there has been renewed interest in combating these diseases not only by modifying energy intake and lifestyle factors, but also by inducing endogenous energy expenditure. This approach has largely been stimulated by the recent recognition that brown adipose tissue (BAT)-long known to promote heat production and energy expenditure in infants and hibernating mammals-also exists in adult humans. This landmark finding relied on the use of clinical fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography, and imaging techniques continue to play a crucial and increasingly central role in understanding BAT physiology and function. Herein, the authors review the origins of BAT imaging, discuss current preclinical and clinical strategies for imaging BAT, and discuss imaging methods that will provide crucial insight into metabolic disease and how it may be treated by modulating BAT activity. (©) RSNA, 2016.

Indexed as

Adipose Tissue, BrownDiagnostic ImagingFluorodeoxyglucose F18HumansMagnetic Resonance ImagingPositron-Emission TomographyPositron Emission Tomography Computed TomographyUltrasonographyFluorodeoxyglucose F18

Identifiers

PMID27322970
PMCPMC4942993

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.