Trial reportJournal of the American Heart Association2016
Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women.
Trial report in Journal of the American Heart Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01742702 (Non-Invasive HaemoDYNAMICs in Primary and Secondary Hypertension), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-Invasive HaemoDYNAMICs in Primary and Secondary Hypertension: the DYNAMIC-study
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Trial
- Cardiometabolic Health During the Climacteric Transition: A Narrative Review of Lifestyle, Physiological, and Nutritional Approaches.Healthcare (Basel, Switzerland) · 2026Review
- Impact of aging on cardiovascular dynamics and heart rate variability during passive head-up tilt.Physiological reports · 2025Article
- Haemodynamics of hyperthyroidism: increased cardiac work and findings related to vasodilatation.European thyroid journal · 2024Article
- Targeted Treatment Reverses Increased Left Cardiac Work in Unilateral vs. Bilateral Primary Aldosteronism.American journal of hypertension · 2024Article
- Accumulating Sedentary Time and Physical Activity From Childhood to Adolescence and Cardiac Function in Adolescence.Journal of the American Heart Association · 2024Article
- Differences in heart rate responses to upright posture are associated with variations in the high-frequency power of heart rate variability.American journal of physiology. Heart and circulatory physiology · 2024Article
- Low length-for-age Z-score within 1 month after birth predicts hyperdynamic circulation at the age of 21 years in rural Malawi.Scientific reports · 2023Article
- Posture-Related Differences in Cardiovascular Function Between Young Men and Women: Study of Noninvasive Hemodynamics in Rural Malawi.Journal of the American Heart Association · 2022Article
- An anthropogenic model of cardiovascular system adaptation to the Earth's gravity as the conceptual basis of pathological anthropology.Journal of physiological anthropology · 2021Review
- Observational
- Changes in hemodynamics associated with metabolic syndrome are more pronounced in women than in men.Scientific reports · 2019Article
- Liquorice ingestion attenuates vasodilatation via exogenous nitric oxide donor but not via β2-adrenoceptor stimulation.PloS one · 2019Article
- Effect of present versus previous smoking on non-invasive haemodynamics.Scientific reports · 2018Article
- Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.BMC medical genetics · 2018Article
- The Influence of Gender and Anthropometry on Haemodynamic Status at Rest and in Response to Graded Incremental Head-Up Tilt in Young, Healthy Adults.Frontiers in physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMen and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex-related differences in supine and upright cardiovascular regulation. METHODS AND
resultsHemodynamics were recorded from 167 men and 167 women of matching age (≈45 years) and body mass index (≈26.5) during passive head-up tilt. None had diabetes mellitus or cardiovascular disease other than hypertension or used antihypertensive medication. Whole-body impedance cardiography, tonometric radial blood pressure, and heart rate variability were analyzed. Results were adjusted for height, smoking, alcohol intake, mean arterial pressure, plasma lipids, and glucose. Supine hemodynamic differences were minor: Men had lower heart rate (-4%) and higher stroke index (+7.5%) than women (P<0.05 for both). Upright systemic vascular resistance was lower (-10%), but stroke index (+15%), cardiac index (+16%), and left cardiac work were clearly higher (+20%) in men than in women (P<0.001 for all). Corresponding results were observed in a subgroup of men and postmenopausal women (n=76, aged >55 years). Heart rate variability analyses showed higher low:high frequency ratios in supine (P<0.001) and upright (P=0.003) positions in men.
conclusionsThe foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01742702.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.