ArticleIntegrative biology : quantitative biosciences from nano to macro2016
Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation.
Article in Integrative biology : quantitative biosciences from nano to macro, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Evaluating Complexity in Orthopedic Tissue-on-a-Chip Systems.Advanced healthcare materials · 2026Review
- Mechanical Cues and Lineage Commitment Govern the Angiogenic Potential of Mesenchymal Cell-Derived Extracellular Vesicles.Advanced biology · 2026Article
- Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Deep and Superficial Debridement Techniques in Lower Extremity Split-thickness Skin Grafting.Plastic and reconstructive surgery. Global open · 2024Article
- Living symbiotic bacteria-involved skin dressing to combat indigenous pathogens for microbiome-based biotherapy toward atopic dermatitis.Bioactive materials · 2023Article
- Article
- The impact of aging and physical training on angiogenesis in the musculoskeletal system.PeerJ · 2022Article
- Predictive value of red blood cell distribution width in septic shock patients with thrombocytopenia: A retrospective study using machine learning.Journal of clinical laboratory analysis · 2021Article
- Hypertension meets osteoarthritis - revisiting the vascular aetiology hypothesis.Nature reviews. Rheumatology · 2021Review
- Single-cell RNA sequencing deconvolutes theInternational journal of biological sciences · 2021Article
- Perfused Platforms to Mimic Bone Microenvironment at the Macro/Milli/Microscale: Pros and Cons.Frontiers in cell and developmental biology · 2021Review
- Smart Porous Multi-Stimulus Polysaccharide-Based Biomaterials for Tissue Engineering.Molecules (Basel, Switzerland) · 2020Review
- Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes.Science advances · 2020Article
- Mechanical Loading Promotes the Expansion of Primitive Osteoprogenitors and Organizes Matrix and Vascular Morphology in Long Bone Defects.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Osteogenic and angiogenic characterization of mandible and femur osteoblasts.Journal of molecular histology · 2019Article
- Self-Healing and Injectable Hydrogel for Matching Skin Flap Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors.Biomaterials science · 2018Article
- Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis.Biomaterials · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Angiogenesis is a process by which new blood vessels emerge from existing vessels through endothelial cell sprouting, migration, proliferation, and tubule formation. Angiogenesis during skeletal growth, homeostasis and repair is a complex and incompletely understood process. As the skeleton adapts to mechanical loading, we hypothesized that mechanical stimulation regulates "osteo-angio" crosstalk in the context of angiogenesis. We showed that conditioned media (CM) from osteoblasts exposed to fluid shear stress enhanced endothelial cell proliferation and migration, but not tubule formation, relative to CM from static cultures. Endothelial cell sprouting was studied using a dual-channel collagen gel-based microfluidic device that mimics vessel geometry. Static CM enhanced endothelial cell sprouting frequency, whereas loaded CM significantly enhanced both frequency and length. Both sprouting frequency and length were significantly enhanced in response to factors released from osteoblasts exposed to fluid shear stress in an adjacent channel. Osteoblasts released angiogenic factors, of which osteopontin, PDGF-AA, IGBP-2, MCP-1, and Pentraxin-3 were upregulated in response to mechanical loading. These data suggest that in vivo mechanical forces regulate angiogenesis in bone by modulating "osteo-angio" crosstalk through release of paracrine factors, which we term "osteokines".
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.