Evidence map›Paper›PMID 27346646›Full record

Trial reportExperimental gerontology2016

Novel all-extremity high-intensity interval training improves aerobic fitness, cardiac function and insulin resistance in healthy older adults.

Chueh-Lung Hwang, Jeung-Ki Yoo, Han-Kyul Kim, Moon-Hyon Hwang, Eileen M Handberg, John W Petersen, Demetra D Christou

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental gerontology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 11 pooled it
32.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 11 syntheses or guidelines pooled it, 143 citations in OpenAlex.

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  7. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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  19. All-Extremity Exercise Training Improves Arterial Stiffness in Older Adults.Medicine and science in sports and exercise · 2017
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Chueh-Lung HwangDept of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States.
Jeung-Ki YooDept of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States.
Han-Kyul KimDept of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States.
Moon-Hyon HwangDept of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States; Division of Health and Exercise Science, Incheon National University, Incheon, Republic of Korea.
Eileen M HandbergDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States.
John W PetersenDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, United States.
Demetra D ChristouDept of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States. Electronic address: ddchristou@ufl.edu.
University of Florida · US

Funding

NIA NIH HHS R21 AG050203
6 · The paper itself

Abstract

Aging is associated with decreased aerobic fitness and cardiac remodeling leading to increased risk for cardiovascular disease. High-intensity interval training (HIIT) on the treadmill has been reported to be more effective in ameliorating these risk factors compared with moderate-intensity continuous training (MICT) in patients with cardiometabolic disease. In older adults, however, weight-bearing activities are frequently limited due to musculoskeletal and balance problems. The purpose of this study was to examine the feasibility and safety of non-weight-bearing all-extremity HIIT in older adults. In addition, we tested the hypothesis that all-extremity HIIT will be more effective in improving aerobic fitness, cardiac function, and metabolic risk factors compared with all-extremity MICT. Fifty-one healthy sedentary older adults (age: 65±1years) were randomized to HIIT (n=17), MICT (n=18) or non-exercise control (CONT; n=16). HIIT (4×4min 90% of peak heart rate; HRpeak) and isocaloric MICT (70% of HRpeak) were performed on a non-weight-bearing all-extremity ergometer, 4×/week for 8weeks under supervision. All-extremity HIIT was feasible in older adults and resulted in no adverse events. Aerobic fitness (peak oxygen consumption; VO2peak) and ejection fraction (echocardiography) improved by 11% (P<0.0001) and 4% (P=0.001), respectively in HIIT, while no changes were observed in MICT and CONT (P≥0.1). Greater improvements in ejection fraction were associated with greater improvements in VO2peak (r=0.57; P<0.0001). Insulin resistance (homeostatic model assessment) decreased only in HIIT by 26% (P=0.016). Diastolic function, body composition, glucose and lipids were unaffected (P≥0.1). In conclusion, all-extremity HIIT is feasible and safe in older adults. HIIT, but not MICT, improved aerobic fitness, ejection fraction, and insulin resistance.

Indexed as

Cardiorespiratory FitnessInsulin ResistanceAgedAgingBody CompositionFemaleFloridaHealthy VolunteersHeart RateHigh-Intensity Interval TrainingHumansLinear ModelsMaleMiddle AgedOxygen ConsumptionRisk FactorsAerobic fitnessAgingCardiac functionHigh-intensity interval trainingMetabolic risk factorsModerate-intensity continuous training

Identifiers

PMID27346646
PMCPMC4975154
OpenAlexW2468182390

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.