← Antihypertensives × all-cause mortality

SynthesisThe Cochrane database of systematic reviews2016

Pharmacological interventions for treating heart failure in patients with Chagas cardiomyopathy.

Arturo J Martí-Carvajal et al.PubMed ↗Full text ↗Publisher ↗

  • Carvedilollooks bad hereLower quality of life measured by Minnesota Living With Heart Failure Questionnaire, no clear effect on deaths, no clear effect on hospital readmissions.Randomised, small.

What the trial testedrandomised · 108 people · 2016

Randomised vs placebo

Probably lowered quality of life measured by Minnesota Living With Heart Failure Questionnaire

−14.7−24.8 to −4.73

carvedilol vs placebo

As reported

difference −14.74, 95% CI −24.8 to −4.73

Range includes no effect

No clear effect on deaths

0.7×0.1× to 3.9×

carvedilol vs placebo

Bigger than 8 in 10 for all-cause mortality

As reported

RR 0.69, 95% CI 0.12–3.88 · the paper's word: all-cause mortality

Range includes no effect

No clear effect on hospital readmissions

1×0.3× to 3.3×

carvedilol vs placebo

Smaller than almost all on the map

As reported

RR 1.00, 95% CI 0.31–3.28

Range includes no effect

No clear effect on adverse events

−8%−33% to +27%

carvedilol vs placebo

Bigger than 3 in 10 for adverse events & safety

As reported

RR 0.92, 95% CI 0.67–1.27

Who was studied, and how

108people with heart failure, in this paper

The trial randomly assignedassigned by chance

carvedilol
placebo

Probably lowered quality of life measured by Minnesota Living With Heart Failure Questionnaire−14.7

No clear effect on deaths0.7×

No clear effect on hospital readmissions1×

randomised

the abstract, start to end

… compared with the placebo groups (RR 0.69; 95% CI 0.12 to 3.88, I² = 0%; …

… difference in hospital readmissions (RR 1.00; 95% CI 0.31 to 3.28; very low-quality of evidence) or reported adverse events (RR 0.92; 95% CI 0.67 to 1.27; very …

The MD was -14.74; 95% CI -24.75 to -4.73.

← favours treatmentfavours comparator →
could be chance
All-cause mortalitycarvedilol vs placebo
RR 0.690.12–3.88
Hospital readmissionscarvedilol vs placebo
RR 1.000.31–3.28
Adverse eventscarvedilol vs placebo
RR 0.920.67–1.27
Quality of life (QoL) measured by Minnesota Living With Heart Failure Questionnairecarvedilol vs placebo
−14.74−24.8 to −4.73
AntihypertensivesAll-cause mortalityAdverse events & safetyQuality of life & behaviourCosts & health-care use
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2016
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Full record →Abstract, authors, funding and every citing paper · PMID 27388039