Evidence map›Paper›PMID 27418379›Full record

Trial reportThe American journal of psychiatry2016

Right Unilateral Ultrabrief Pulse ECT in Geriatric Depression: Phase 1 of the PRIDE Study.

Charles H Kellner, Mustafa M Husain, Rebecca G Knapp, W Vaughn McCall, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shirlene Sampson, Shawn M McClintock, Martina Mueller and 15 more

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
25.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04399070 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of S-ketamine on Depressed Patients Undergoing Electroconvulsive Therapy-a Randomized, Double-blind, Controlled Clinical Study

TypeinterventionalSponsorYan QiuRan2020 to 2021Enrolled150ConditionsDepression, Bipolar, Depression, Unipolar, Major Depressive Disorder, Manic-Depressive - Now DepressedArmsS-ketamine, ketamine, saline
NCT05923801 narecruitingnot on this mapstarted 2023, after this paper: background citation

Changing Tactics? Optimizing ECT in Difficult-to-treat Depression: A Randomized Trial Comparing Continuation of Right Unilateral ECT and Switching to Bitemporal ECT in Case of Early Non-response During an Acute Course of ECT for Difficult-to-treat Depression

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2023 to 2026Enrolled196ConditionsDepressionArmsswitch to BT electrode position, continue with RUL electrode position
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 258 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Extended course accelerated intermittent theta burst stimulation as a substitute for depressed patients needing electroconvulsive therapy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Trial
  4. Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Trial
  5. Longitudinal Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Pharmacotherapy in Major Depressive Disorder in Older Adults: Phase 2 of the PRIDE Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Trial
  6. Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Trial
  7. Trial
  8. Seizure threshold increases can be predicted by EEG quality in right unilateral ultrabrief ECT.European archives of psychiatry and clinical neuroscience · 2017
    Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Observational
  19. Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Charles H KellnerFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Mustafa M HusainFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Rebecca G KnappFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
W Vaughn McCallFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Georgios PetridesFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Matthew V RudorferFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Robert C YoungFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Shirlene SampsonFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Shawn M McClintockFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Martina MuellerFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Joan PrudicFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Robert M GreenbergFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Richard D WeinerFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Samuel H BailineFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Peter B RosenquistFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Ahmad RazaFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Styliani KalioraFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Vassilios LatoussakisFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Kristen G TobiasFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Mimi C BriggsFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Lauren S LiebmanFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Emma T GeduldigFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Abeba A TeklehaimanotFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Sarah H LisanbyFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
CORE/PRIDE Work GroupFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/North Shore-LIJ Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
NewYork–Presbyterian Hospital · USCornell University · US

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
2/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH084241 · NIMH · DUKE UNIVERSITY · PI WEINER, RICHARD D. · 2009 to 2013
$2.1M
1/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH055495 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLNER, CHARLES H · 2009 to 2013
$2.0M
3/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH081362 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KNAPP, REBECCA GRANT · 2009 to 2013
$1.8M
Treatment of Bipolar Disorder in Old AgeK02MH067028 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2003 to 2013
$1.2M
7/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086127 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCALL, WILLIAM VAUGHN · 2009 to 2013
$1.1M
8/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086122 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2009 to 2013
$1.0M
5/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086130 · NIMH · MAYO CLINIC ROCHESTER · PI SAMPSON, SHIRLENE MARIE · 2009 to 2011
$610k
NIMH NIH HHS K02 MH067028NIMH NIH HHS U01 MH055495NIMH NIH HHS U01 MH081362NIMH NIH HHS U01 MH084241NIMH NIH HHS U01 MH086122NIMH NIH HHS U01 MH086127NIMH NIH HHS U01 MH086130
6 · The paper itself

Abstract

objectiveThe Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy of right unilateral ultrabrief pulse electroconvulsive therapy (ECT) combined with venlafaxine for the treatment of geriatric depression.

methodPRIDE was a two-phase multisite study. Phase 1 was an acute course of right unilateral ultrabrief pulse ECT, combined with open-label venlafaxine at seven academic medical centers. In phase 2 (reported separately), patients who had remitted were randomly assigned to receive pharmacotherapy (venlafaxine plus lithium) or pharmacotherapy plus continuation ECT. In phase 1, depressed patients received high-dose ECT (at six times the seizure threshold) three times per week. Venlafaxine was started during the first week of treatment and continued throughout the study. The primary outcome measure was remission, assessed with the 24-item Hamilton Depression Rating Scale (HAM-D), which was administered three times per week. Secondary outcome measures were post-ECT reorientation and safety. Paired t tests were used to estimate and evaluate the significance of change from baseline in HAM-D scores.

resultsOf 240 patients who entered phase 1 of the study, 172 completed it. Overall, 61.7% (148/240) of all patients met remission criteria, 10.0% (24/240) did not remit, and 28.3% (68/240) dropped out; 70% (169/240) met response criteria. Among those who remitted, the mean decrease in HAM-D score was 24.7 points (95% CI=23.4, 25.9), with a mean final score of 6.2 (SD=2.5) and an average change from baseline of 79%. The mean number of ECT treatments to remission was 7.3 (SD=3.1).

conclusionsRight unilateral ultrabrief pulse ECT, combined with venlafaxine, is a rapidly acting and highly effective treatment option for depressed geriatric patients, with excellent safety and tolerability. These data add to the evidence base supporting the efficacy of ECT to treat severe depression in elderly patients.

Indexed as

AgedAged, 80 and overAntidepressive Agents, Second-GenerationCombined Modality TherapyDepressionElectroconvulsive TherapyFemaleHumansMaleMiddle AgedTreatment OutcomeVenlafaxine HydrochlorideAntidepressive Agents, Second-GenerationVenlafaxine Hydrochloride

Identifiers

PMID27418379
PMCPMC7130447
OpenAlexW2467695657

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.