Evidence map›Paper›PMID 27418381›Full record

Trial reportThe American journal of psychiatry2016

A Novel Strategy for Continuation ECT in Geriatric Depression: Phase 2 of the PRIDE Study.

Charles H Kellner, Mustafa M Husain, Rebecca G Knapp, W Vaughn McCall, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shirlene Sampson, Shawn M McClintock, Martina Mueller and 16 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04399070 (Effect of S-ketamine on Depressed Patients Undergoing Electroconvulsive Therapy-a Randomized, Double-blind, Controlled Clinical Study), which is not on this map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04399070 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of S-ketamine on Depressed Patients Undergoing Electroconvulsive Therapy-a Randomized, Double-blind, Controlled Clinical Study

TypeinterventionalSponsorYan QiuRan2020 to 2021Enrolled150ConditionsDepression, Bipolar, Depression, Unipolar, Major Depressive Disorder, Manic-Depressive - Now DepressedArmsS-ketamine, ketamine, saline
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Trial
  9. Longitudinal Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Pharmacotherapy in Major Depressive Disorder in Older Adults: Phase 2 of the PRIDE Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022
    Trial
  10. Trial
  11. Trial
  12. Preventing relapse in patients with major depressive disorder after an effective acute course of electroconvulsive therapy.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2026
    Review
  13. Review
  14. Remission is insufficient: predictors and mechanistic models of recurrence in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Charles H KellnerFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Mustafa M HusainFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Rebecca G KnappFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
W Vaughn McCallFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Georgios PetridesFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Matthew V RudorferFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Robert C YoungFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Shirlene SampsonFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Shawn M McClintockFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Martina MuellerFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Joan PrudicFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Robert M GreenbergFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Richard D WeinerFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Samuel H BailineFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Peter B RosenquistFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Ahmad RazaFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Styliani KalioraFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Vassilios LatoussakisFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Kristen G TobiasFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Mimi C BriggsFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Lauren S LiebmanFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Emma T GeduldigFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Abeba A TeklehaimanotFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Mary DooleyFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
Sarah H LisanbyFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.
CORE/PRIDE Work GroupFrom the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York; the Department of Psychiatry, Columbia University and New York State Psychiatric Institute, New York; the Department of Psychiatry and Behavioral Health Sciences, NYU Lutheran Medical Center, New York; the Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston; the Department of Psychiatry, Zucker Hillside Hospital/Northwell Health System, New York; the Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas; the Department of Psychiatry, New York Presbyterian/Weill Cornell Medical Center, New York and White Plains; the Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, N.C.; the Department of Psychiatry and Health Behavior, Augusta University/Medical College of Georgia, Augusta; the Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Rochester, Minn.; and the Division of Services and Intervention Research, NIMH, Bethesda, Md.

Funding

Non-invasive Neuromodulation Unit (NNU)ZIAMH002955 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2016 to 2025
$40.3M
2/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH084241 · NIMH · DUKE UNIVERSITY · PI WEINER, RICHARD D. · 2009 to 2013
$2.1M
1/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH055495 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KELLNER, CHARLES H · 2009 to 2013
$2.0M
3/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH081362 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KNAPP, REBECCA GRANT · 2009 to 2013
$1.8M
Treatment of Bipolar Disorder in Old AgeK02MH067028 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2003 to 2013
$1.2M
7/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086127 · NIMH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCALL, WILLIAM VAUGHN · 2009 to 2013
$1.1M
8/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086122 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI YOUNG, ROBERT C. · 2009 to 2013
$1.0M
5/8-Prolonging Remission in Depressed Elderly (PRIDE)U01MH086130 · NIMH · MAYO CLINIC ROCHESTER · PI SAMPSON, SHIRLENE MARIE · 2009 to 2011
$610k
NIMH NIH HHS K02 MH067028NIMH NIH HHS U01 MH055495NIMH NIH HHS U01 MH081362NIMH NIH HHS U01 MH084241NIMH NIH HHS U01 MH086122NIMH NIH HHS U01 MH086127NIMH NIH HHS U01 MH086130
6 · The paper itself

Abstract

objectiveThe randomized phase (phase 2) of the Prolonging Remission in Depressed Elderly (PRIDE) study evaluated the efficacy and tolerability of continuation ECT plus medication compared with medication alone in depressed geriatric patients after a successful course of ECT (phase 1).

methodPRIDE was a two-phase multisite study. Phase 1 was an acute course of right unilateral ultrabrief pulse ECT, augmented with venlafaxine. Phase 2 compared two randomized treatment arms: a medication only arm (venlafaxine plus lithium, over 24 weeks) and an ECT plus medication arm (four continuation ECT treatments over 1 month, plus additional ECT as needed, using the Symptom-Titrated, Algorithm-Based Longitudinal ECT [STABLE] algorithm, while continuing venlafaxine plus lithium). The intent-to-treat sample comprised 120 remitters from phase 1. The primary efficacy outcome measure was score on the 24-item Hamilton Depression Rating Scale (HAM-D), and the secondary efficacy outcome was score on the Clinical Global Impressions severity scale (CGI-S). Tolerability as measured by neurocognitive performance (reported elsewhere) was assessed using an extensive test battery; global cognitive functioning as assessed by the Mini-Mental State Examination (MMSE) is reported here. Longitudinal mixed-effects repeated-measures modeling was used to compare ECT plus medication and medication alone for efficacy and global cognitive function outcomes.

resultsAt 24 weeks, the ECT plus medication group had statistically significantly lower HAM-D scores than the medication only group. The difference in adjusted mean HAM-D scores at study end was 4.2 (95% CI=1.6, 6.9). Significantly more patients in the ECT plus medication group were rated "not ill at all" on the CGI-S compared with the medication only group. There was no statistically significant difference between groups in MMSE score.

conclusionsAdditional ECT after remission (here operationalized as four continuation ECT treatments followed by further ECT only as needed) was beneficial in sustaining mood improvement for most patients.

Indexed as

AgedAged, 80 and overCombined Modality TherapyDepressionDouble-Blind MethodElectroconvulsive TherapyFemaleHumansLithiumMaleMiddle AgedTreatment OutcomeVenlafaxine HydrochlorideLithiumVenlafaxine Hydrochloride

Identifiers

PMID27418381
PMCPMC7130448

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.