Metformin × adverse events & safety

TrialCirculation research2016

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status.

Amy R Cameron et al.PubMed ↗Full text ↗Publisher ↗

  • Metformincuts both waysHigher likelihood that neutrophil to lymphocyte ratio would be lower than baseline.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Metformin went with higher likelihood that neutrophil to lymphocyte ratio would be lower than baseline

1.8×1.2× to 2.8×

metformin vs sulfonylurea, in nondiabetic diabetes mellitus population

Bigger than 8 in 10 for adverse events & safety

As reported

OR 1.83, 95% CI 1.22–2.75

+1 more in the walkthrough ↓

Who was studied, and how

62people in the Metformin in Insulin Resistant LV Dysfunction, a Double-blind, Placebo-controlled Trial trial, from 2007
of them with type 2 diabetes, in this paper

Already taking metformin, or nottheir own situation, not assigned

on metformin
sulfonylurea

Metformin went with higher likelihood that neutrophil to lymphocyte ratio would be lower than baseline1.8×

correlation, not a test

the abstract, start to end

lymphocyte ratio after 8 to 16 months by 0.09 U (95% confidence interval, 0.02-0.17; P=0.013) and increased the likelihood that neutrophil to lymphocyte ratio would be lower than baseline after 8 to 16 months (odds ratio, 1.83; 95% confidence interval,

← favours treatmentfavours comparator →
could be chance
Mean log-transformed neutrophil to lymphocyte ratiometformin vs sulfonylurea, in nondiabetic diabetes mellitus population
−0.09−0.17 to −0.02
Likelihood that neutrophil to lymphocyte ratio would be lower than baselinemetformin vs sulfonylurea, in nondiabetic diabetes mellitus population
OR 1.831.22–2.75
MetforminAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 27418629