ArticleAnalytical chemistry2016
Rapid Detection of Bacteria from Blood with Surface-Enhanced Raman Spectroscopy.
Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent advances in surface enhanced Raman spectroscopy for bacterial pathogen identifications.Journal of advanced research · 2023Pooled it
- A novel width-expanding spiral microchannel for high-throughput continuous separation of bacterial-sized particles.Scientific reports · 2026Article
- Design Principles of Nanosensors for Multiplex Detection of Contaminants in Food.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Unveiling the Molecular Secrets: A Comprehensive Review of Raman Spectroscopy in Biological Research.ACS omega · 2024Review
- Recent trends and impact of localized surface plasmon resonance (LSPR) and surface-enhanced Raman spectroscopy (SERS) in modern analysis.Journal of pharmaceutical analysis · 2024Review
- Fluorescent carbon dots for discriminating cell types: a review.Analytical and bioanalytical chemistry · 2024Review
- SERS-based rapid susceptibility testing of commonly administered antibiotics on clinically important bacteria species directly from blood culture of bacteremia patients.World journal of microbiology & biotechnology · 2023Article
- Luminescent Guests Encapsulated in Metal-Organic Frameworks for Portable Fluorescence Sensor and Visual Detection Applications: A Review.Biosensors · 2023Review
- AIEgen-Based Nanomaterials for Bacterial Imaging and Antimicrobial Applications: Recent Advances and Perspectives.Molecules (Basel, Switzerland) · 2023Review
- Optical Methods for Label-Free Detection of Bacteria.Biosensors · 2022Review
- Article
- Application of SERS in the Detection of Fungi, Bacteria and Viruses.Nanomaterials (Basel, Switzerland) · 2022Review
- Highly Accurate Identification of Bacteria's Antibiotic Resistance Based on Raman Spectroscopy and U-Net Deep Learning Algorithms.ACS omega · 2022Article
- Rapid, Label-Free Prediction of Antibiotic Resistance inInternational journal of molecular sciences · 2022Article
- Machine learning analysis of SERS fingerprinting for the rapid determination ofComputational and structural biotechnology journal · 2022Article
- Rapid Discrimination of Clinically Important Pathogens Through Machine Learning Analysis of Surface Enhanced Raman Spectra.Frontiers in microbiology · 2022Article
- Review
- Challenges of SERS technology as a non-nucleic acid or -antigen detection method for SARS-CoV-2 virus and its variants.Biosensors & bioelectronics · 2021Review
- Mode of Action of Disinfection Chemicals on the Bacterial Spore Structure and Their Raman Spectra.Analytical chemistry · 2021Article
- Applications of Raman Spectroscopy in Bacterial Infections: Principles, Advantages, and Shortcomings.Frontiers in microbiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Traditional methods for identifying pathogens in bacteremic patients are slow (24-48+ h). This can lead to physicians making treatment decisions based on an incomplete diagnosis and potentially increasing the patient's mortality risk. To decrease time to diagnosis, we have developed a novel technology that can recover viable bacteria directly from whole blood and identify them in less than 7 h. Our technology combines a sample preparation process with surface-enhanced Raman spectroscopy (SERS). The sample preparation process enriches viable microorganisms from 10 mL of whole blood into a 200 μL aliquot. After a short incubation period, SERS is used to identify the microorganisms. We further demonstrated that SERS can be used as a broad detection method, as it identified a model set of 17 clinical blood culture isolates and microbial reference strains with 100% identification agreement. By applying the integrated technology of sample preparation and SERS to spiked whole blood samples, we were able to correctly identify both Staphylococcus aureus and Escherichia coli 97% of the time with 97% specificity and 88% sensitivity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.