Evidence map›Paper›PMID 27431361›Full record

ArticleEuropean journal of immunology2016

Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor.

Mara L Lennard Richard, Danielle Brandon, Ning Lou, Shuzo Sato, Tomika Caldwell, Tamara K Nowling, Gary Gilkeson, Xian K Zhang

Abstract read
In one paragraph

Article in European journal of immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Enhanced ApcNeoplasia (New York, N.Y.) · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Fli-1 Governs Pericyte Dysfunction in a Murine Model of Sepsis.The Journal of infectious diseases · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mara L Lennard RichardDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Danielle BrandonDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Ning LouDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Shuzo SatoDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Tomika CaldwellDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Tamara K NowlingDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Gary GilkesonDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA.
Xian K ZhangDepartment of Medicine, Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, USA. zhangjo@musc.edu.
Medical University of South Carolina · USShandong University · CN

Funding

Molecular mechanisms of the impact of Fli-1 on lupusR01AR056670 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ZHANG, XIAN · 2010 to 2014
$1.4M
NIAMS NIH HHS R01 AR056670
6 · The paper itself

Abstract

Fli-1 has emerged as a critical regulator of inflammatory mediators, including MCP-1, CCL5, and IL-6. The cytokine, granulocyte colony stimulating factor (G-CSF) regulates neutrophil precursor maturation and survival, and activates mature neutrophils. Previously, a significant decrease in neutrophil infiltration into the kidneys of Fli-1

Indexed as

AcetylationAnimalsEndothelial CellsGene Expression RegulationGranulocyte Colony-Stimulating FactorHumansHuman Umbilical Vein Endothelial CellsInflammationMiceMutationNeutrophilsPromoter Regions, GeneticProtein BindingRNA, Small InterferingVascular Endothelial Growth Factor Receptor-1Flt1 protein, mouseGranulocyte Colony-Stimulating FactorRNA, Small InterferingVascular Endothelial Growth Factor Receptor-1CytokinesFli-1G-CSFGene regulationInflammationTranscriptional factors

Identifiers

PMID27431361
PMCPMC5175580
OpenAlexW2488737582

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.