ArticleOncotarget2017
Ultraconserved long non-coding RNA uc.63 in breast cancer.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- LEADR, a p63 target, dampens interferon signalling in bladder cancer.Cell death discovery · 2025Article
- The transcribed ultraconserved regions: emerging players in colorectal cancer biology and therapy.Frontiers in cell and developmental biology · 2025Review
- Involvement of transcribed lncRNA uc.291 in hyperproliferative skin disorders.Biology direct · 2023Article
- Epigenetic Alterations in DCIS Progression: What Can lncRNAs Teach Us?International journal of molecular sciences · 2023Review
- Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential.Discover oncology · 2023Review
- Transcribed Ultraconserved Regions: New regulators in cancer signaling and potential biomarkers.Genetics and molecular biology · 2023Article
- Long non-coding RNAs affecting cell metabolism in cancer.Biology direct · 2022Review
- Transcribed Ultraconserved Regions in Cancer.Cells · 2022Review
- Analysis of Long Non-Coding RNA (lncRNA) uc.38 and uc.63 Expression in Breast Carcinoma Patients.Genes · 2022Article
- Transcribed Ultraconserved Regions Are Associated with Clinicopathological Features in Breast Cancer.Biomolecules · 2022Article
- Coding roles of long non-coding RNAs in breast cancer: Emerging molecular diagnostic biomarkers and potential therapeutic targets with special reference to chemotherapy resistance.Frontiers in genetics · 2022Review
- A novel lncRNA derived from an ultraconserved region: lnc-RNA biology · 2021Article
- The Role of lncRNA in the Development of Tumors, including Breast Cancer.International journal of molecular sciences · 2021Review
- Uc.63+ contributes to gastric cancer progression through regulation of NF-kB signaling.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex.EMBO reports · 2020Article
- Unveiling ncRNA regulatory axes in atherosclerosis progression.Clinical and translational medicine · 2020Review
- The Transcribed-Ultra Conserved Regions: Novel Non-Coding RNA Players in Neuroblastoma Progression.Non-coding RNA · 2019Review
- Uc.416 + A promotes epithelial-to-mesenchymal transition through miR-153 in renal cell carcinoma.BMC cancer · 2018Article
- Deciphering the roles of lncRNAs in breast development and disease.Oncotarget · 2018Review
- Expression of uc.189 and its clinicopathologic significance in gynecological cancers.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (lncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.