Evidence map›Paper›PMID 27455318›Full record

ArticleNutrients2016

Impact of Diabetes-Specific Nutritional Formulas versus Oatmeal on Postprandial Glucose, Insulin, GLP-1 and Postprandial Lipidemia.

Adham Mottalib, Barakatun-Nisak Mohd-Yusof, Mohamed Shehabeldin, David M Pober, Joanna Mitri, Osama Hamdy

Open access · goldAbstract readComparative StudyControlled Clinical Trial
In one paragraph

Article in Nutrients, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Adham MottalibJoslin Diabetes Center, Boston, MA 02215, USA. adham.mottalib@joslin.harvard.edu.
Barakatun-Nisak Mohd-YusofJoslin Diabetes Center, Boston, MA 02215, USA. Barakatun.Nisak-Mohd-Yusof@joslin.harvard.edu.
Mohamed ShehabeldinJoslin Diabetes Center, Boston, MA 02215, USA. moshehabeldin@gmail.com.
David M PoberJoslin Diabetes Center, Boston, MA 02215, USA. david.pober@joslin.harvard.edu.
Joanna MitriJoslin Diabetes Center, Boston, MA 02215, USA. joanna.mitri@joslin.harvard.edu.
Osama HamdyJoslin Diabetes Center, Boston, MA 02215, USA. osama.hamdy@joslin.harvard.edu.
Joslin Diabetes Center · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

Diabetes-specific nutritional formulas (DSNFs) are frequently used as part of medical nutrition therapy for patients with diabetes. This study aims to evaluate postprandial (PP) effects of 2 DSNFs; Glucerna (GL) and Ultra Glucose Control (UGC) versus oatmeal (OM) on glucose, insulin, glucagon-like peptide-1 (GLP-1), free fatty acids (FFA) and triglycerides (TG). After an overnight fast, 22 overweight/obese patients with type 2 diabetes were given 200 kcal of each of the three meals on three separate days in random order. Blood samples were collected at baseline and at 30, 60, 90, 120, 180 and 240 min. Glucose area under the curve (AUC0-240) after GL and UGC was lower than OM (p < 0.001 for both). Insulin positive AUC0-120 after UGC was higher than after OM (p = 0.02). GLP-1 AUC0-120 and AUC0-240 after GL and UGC was higher than after OM (p < 0.001 for both). FFA and TG levels were not different between meals. Intake of DSNFs improves PP glucose for 4 h in comparison to oatmeal of similar caloric level. This is achieved by either direct stimulation of insulin secretion or indirectly by stimulating GLP-1 secretion. The difference between their effects is probably related to their unique blends of amino acids, carbohydrates and fat.

Indexed as

Food, FormulatedAgedAvenaBody Mass IndexCross-Over StudiesDiabetes Mellitus, Type 2Dietary CarbohydratesDietary Fats, UnsaturatedDiet, DiabeticDiet, ReducingFemaleGlucagon-Like Peptide 1Glycated HemoglobinGlycemic IndexHumansHyperglycemiaDietary CarbohydratesDietary Fats, UnsaturatedGlucagon-Like Peptide 1GlucernaGlycated Hemoglobinhemoglobin A1c protein, humanclinical nutritiondiabetesmeal replacementmedical foodnutritional formulaobesity

Identifiers

PMID27455318
PMCPMC4963919
OpenAlexW2483639469

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.