Evidence map›Paper›PMID 27457635›Full record

SynthesisDiabetes care2016

Metabolic Effects of Monounsaturated Fatty Acid-Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid-Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Frank Qian, Andres Ardisson Korat, Vasanti Malik, Frank B Hu

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06818032 (Acute Avocado Consumption on Postprandial Glycemic and Appetite/Satiety Responses), which is not on this map. Cited by 96 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 9 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06818032 nacompletednot on this mapstarted 2025, after this paper: background citation

Acute Avocado Consumption on Postprandial Glycemic and Appetite/Satiety Responses

TypeinterventionalSponsorUniversity of Vermont Medical CenterRan2025 to 2026Enrolled30ConditionsHealthy, Healthy Volunteer, Healthy Volunteers, Healthy AdultArmsNegative control, Avocado, Fat and fiber addition
3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 9 syntheses or guidelines pooled it, 216 citations in OpenAlex.

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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Frank QianPritzker School of Medicine, The University of Chicago, Chicago, IL.
Andres Ardisson KoratDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Vasanti MalikDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Frank B HuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA frank.hu@channing.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USUniversity of Chicago · US

Funding

BIOCHEMICAL AND GENETIC MARKERS OF TYPE 2 DIABETES RISKR01DK058845 · BRIGHAM AND WOMEN'S HOSPITAL · 2001 to 2005
$3.0M
TRAINING GRANT IN ACADEMIC NUTRITIONT32DK007703 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 1994 to 2025
$2.1M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 1998 to 2005
$763k
NHLBI NIH HHS R01 HL060712NIDDK NIH HHS R01 DK058845NIDDK NIH HHS T32 DK007703
6 · The paper itself

Abstract

objectiveDietary interventions in patients with type 2 diabetes (T2D) are important for preventing long-term complications. Although a healthy diet is crucial, there is still uncertainty about the optimal macronutrient composition. We performed a meta-analysis comparing diets high in cis-monounsaturated fatty acids (MUFA) to diets high in carbohydrates (CHO) or in polyunsaturated fatty acids (PUFA) on metabolic risk factors in patients with T2D. RESEARCH DESIGN AND

methodsWe systematically reviewed PubMed, MEDLINE, and Cochrane databases and prior systematic reviews and meta-analyses to identify interventions assessing HbA1c, fasting plasma glucose and insulin, LDL and HDL cholesterol, triglycerides, body weight, or systolic/diastolic blood pressure. Meta-analyses were conducted using both fixed- and random-effects models to calculate the weighted mean difference (WMD) and 95% CI.

resultsWe identified 24 studies totaling 1,460 participants comparing high-MUFA to high-CHO diets and 4 studies totaling 44 participants comparing high-MUFA to high-PUFA diets. When comparing high-MUFA to high-CHO diets, there were significant reductions in fasting plasma glucose (WMD -0.57 mmol/L [95% CI -0.76, -0.39]), triglycerides (-0.31 mmol/L [-0.44, -0.18]), body weight (-1.56 kg [-2.89, -0.23]), and systolic blood pressure (-2.31 mmHg [-4.13, -0.49]) along with significant increases in HDL cholesterol (0.06 mmol/L [0.02, 0.10]). When high-MUFA diets were compared with high-PUFA diets, there was a significant reduction in fasting plasma glucose (-0.87 mmol/L [-1.67, -0.07]). All of the outcomes had low to medium levels of heterogeneity, ranging from 0.0 to 69.5% for diastolic blood pressure (Phet = 0.011).

conclusionsOur meta-analysis provides evidence that consuming diets high in MUFA can improve metabolic risk factors among patients with T2D.

Indexed as

DietBlood GlucoseBlood PressureBody WeightCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 2Dietary CarbohydratesDiet, High-FatFatty Acids, MonounsaturatedFatty Acids, UnsaturatedGlycated HemoglobinHumansInsulinRandomized Controlled Trials as TopicTriglyceridesBlood GlucoseCholesterol, HDLCholesterol, LDLDietary CarbohydratesFatty Acids, MonounsaturatedFatty Acids, UnsaturatedGlycated HemoglobinInsulinTriglycerides

Identifiers

PMID27457635
PMCPMC4955926
OpenAlexW2482481232

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.