ArticleMenopause (New York, N.Y.)2016
Cardiovascular, hemodynamic, neuroendocrine, and inflammatory markers in women with and without vasomotor symptoms.
Article in Menopause (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?Frontiers in neuroendocrinology · 2020Pooled it
- IL-6 Response to Psychosocial Stress Predicts 12-month Changes in Cardiometabolic Biomarkers in Perimenopausal Women.The Journal of clinical endocrinology and metabolism · 2020Trial
- The Effect of Perimenopausal Transdermal Estradiol and Micronized Progesterone on Markers of Risk for Arterial Disease.The Journal of clinical endocrinology and metabolism · 2020Trial
- Substance use and menopausal hormone therapy: Treatment initiation and interruption among US women with and without HIV, 2008-2019.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Adverse childhood experiences, age at menopause, and vasomotor symptoms among mid-life Latine adults in California.Evolutionary human sciences · 2026Article
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Neurokinin Antagonists to Treat Vasomotor Symptoms-Possible Implications for Long-Term Health and Disease.Journal of clinical medicine · 2025Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Association Between Protein-Rich Foods, Nutritional Supplements, and Age of Natural Menopause and Its Symptoms.Nutrients · 2025Article
- Reproductive aging in biological females: mechanisms and immediate consequences.Frontiers in endocrinology · 2025Review
- Vasomotor symptoms and their links to cardiovascular disease risk.Current opinion in endocrine and metabolic research · 2023Article
- The longitudinal relation of inflammation to incidence of vasomotor symptoms.Menopause (New York, N.Y.) · 2022Article
- Sex hormones and immune system: Menopausal hormone therapy in the context of COVID-19 pandemic.Frontiers in immunology · 2022Review
- Article
- Hypothalamic-pituitary-adrenal axis, subjective, and thermal stress responses in midlife women with vasomotor symptoms.Menopause (New York, N.Y.) · 2020Article
- Vasomotor menopausal symptoms and risk of cardiovascular disease: a pooled analysis of six prospective studies.American journal of obstetrics and gynecology · 2020Article
- Relationship of the neutrophil/lymphocyte ratio with cardiovascular risk markers in premenopausal and postmenopausal women.Przeglad menopauzalny = Menopause review · 2020Article
- Impact of Estradiol Variability and Progesterone on Mood in Perimenopausal Women With Depressive Symptoms.The Journal of clinical endocrinology and metabolism · 2020Observational
- Childhood abuse and vasomotor symptoms among midlife women.Menopause (New York, N.Y.) · 2019Article
- Vasomotor symptom characteristics: are they risk factors for incident diabetes?Menopause (New York, N.Y.) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveVasomotor symptoms (VMS) may be associated with an increased risk of cardiovascular disease. One candidate mechanism may involve alterations in physiological responses to stress. The current study therefore examined the relationship between self-reported VMS bother and cardiovascular, hemodynamic, neuroendocrine, and inflammatory responses to an acute psychosocial stress protocol.
methodsOne hundred eighty-six women in the menopausal transition or early postmenopausal stage (age 45-60 y) provided the data for this article. Subjective hot flash and night sweat bother were assessed using the Greene Climacteric Scale. Women also underwent a stressor battery involving a speech and a mental arithmetic task while cardiovascular, hemodynamic, neuroendocrine, and inflammatory responses were assessed. Repeated measures regression analyses were used to examine the relationship between self-reported VMS and physiologic responses to the stressor.
resultsIn multivariate analyses adjusting for potential confounders, self-reported hot flash bother was associated with lower overall cardiac index and stroke volume index and higher overall vascular resistance index and levels of the inflammatory cytokine interleukin-6. Hot flash bother also tended to be associated with higher overall cortisol levels and higher baseline levels of plasma norepinephrine. Night sweat bother, on the other hand, was associated with higher overall cortisol levels and tended to be associated with higher interleukin-6.
conclusionsSelf-reported VMS bother is associated with an unfavorable hemodynamic and neuroendocrine profile characterized by increased hypothalamic-pituitary-adrenal axis and central sympathetic activation, inflammation, and vasoconstriction. Further research investigating this profile in relation to VMS, and the potential health implications of this association, is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.